Department of Biomedical, Dental, Morphological and Functional Sciences, University of Messina, Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Curr Pharm Des. 2021;27(18):2151-2155. doi: 10.2174/1381612827666210208154105.
Vascular inflammation is responsible for many cardiovascular diseases and endothelial dysfunction is often the first trigger. Many factors can contribute to altering vascular homeostasis and despite that some risk factors cannot be changed, some lifestyle changes might dramatically improve vascular function. In this regard, physical activity has been identified as one of the most important interventions that can positively affect endothelial dysfunction. In recent years, the discovery of irisin, a novel myokine with pleiotropic effects, has caught the attention of many researchers. This review summarizes the most relevant intervention trials, evaluating irisin modifications in subjects with or without cardiovascular risk factors assigned to physical activity programs, to improve cardiovascular risk markers.
血管炎症是许多心血管疾病的罪魁祸首，内皮功能障碍通常是第一个触发因素。许多因素都可能导致血管稳态的改变，尽管有些风险因素无法改变，但一些生活方式的改变可能会显著改善血管功能。在这方面，体育活动已被确定为可以对内皮功能障碍产生积极影响的最重要干预措施之一。近年来，一种具有多种效应的新型肌因子鸢尾素的发现引起了许多研究人员的关注。这篇综述总结了最相关的干预试验，评估了有或没有心血管危险因素的受试者在进行体育活动方案时鸢尾素的变化，以改善心血管风险标志物。
