Division of Sport Science, College of Arts & Physical Education, Incheon National University, Incheon 22012, Korea.
Sport Science Institute, College of Arts & Physical Education, Incheon National University, Incheon 22012, Korea.
Int J Mol Sci. 2020 Sep 29;21(19):7184. doi: 10.3390/ijms21197184.
Exercise is an effective intervention for both the prevention and the treatment of obesity and insulin resistance because skeletal muscle secretes many bioactive proteins that contribute to the beneficial effect of exercise. It has been revealed that irisin plays an important role in metabolic homeostasis and both acute and chronic exercises increase circulating irisin in experimental animal models and in humans. Although previous studies have reported that the irisin-related signaling mechanism may play a beneficial role in the treatment of metabolic diseases including obesity, metabolic syndrome, insulin resistance, and diabetes mellitus, studies on whether irisin plays a key role in vascular function and vascular complications are still insufficient. Therefore, the current review aims to summarize the accumulating evidence showing the potential role of irisin, especially in vascular reactivity and vascular abnormalities such as atherosclerosis.
运动是预防和治疗肥胖和胰岛素抵抗的有效干预措施，因为骨骼肌分泌许多生物活性蛋白，有助于发挥运动的有益作用。已经发现，鸢尾素在代谢稳态中起着重要作用，急性和慢性运动均可增加实验动物模型和人类的循环鸢尾素水平。尽管先前的研究报告称，鸢尾素相关信号机制可能在治疗肥胖症、代谢综合征、胰岛素抵抗和糖尿病等代谢疾病方面发挥有益作用，但关于鸢尾素是否在血管功能和血管并发症中起关键作用的研究仍不够充分。因此，本综述旨在总结越来越多的证据，表明鸢尾素的潜在作用，特别是在血管反应性和血管异常（如动脉粥样硬化）方面。
