van den Besselaar A M, Hermans J, Beeser H, Loeliger E A
Department of Haematology, University Hospital, Leiden, The Netherlands.
Br J Haematol. 1988 Mar;68(3):321-8. doi: 10.1111/j.1365-2141.1988.tb04209.x.
Three certified reference materials for thromboplastins are available from the Community Bureau of Reference (BCR) of the European Commission for calibration of commercial thromboplastins used for control of oral anticoagulant therapy. The long-term stability of these reference materials has been monitored by two independent laboratories, using deep-frozen and lyophilized plasma samples. Prothrombin times and prothrombin time ratios measured on 19 occasions in the period 1981-86 have been analysed for trend with time. Although significant trends of prothrombin time and ratio (P less than 0.05) were observed, a consistent pattern of trends could not be recognized. The significant trends of prothrombin time and prothrombin time ratio are most probably due to changes in local laboratory conditions. There is no indication that the reference materials have deteriorated since the beginning of the study. It is recommended that long-term stability monitoring of thromboplastins be performed by at least two laboratories simultaneously.
欧洲委员会标准物质与测量研究所（BCR）提供了三种用于校准口服抗凝治疗所用商业凝血活酶的凝血活酶标准参考物质。两个独立实验室使用深度冷冻和冻干血浆样本监测了这些参考物质的长期稳定性。对1981年至1986年期间19次测量的凝血酶原时间和凝血酶原时间比值进行了随时间变化趋势分析。尽管观察到凝血酶原时间和比值有显著趋势（P小于0.05），但无法识别出一致的趋势模式。凝血酶原时间和凝血酶原时间比值的显著趋势很可能是由于当地实验室条件的变化。没有迹象表明自研究开始以来参考物质已经变质。建议至少由两个实验室同时进行凝血活酶的长期稳定性监测。
