Linsinger Thomas P J, van den Besselaar Anton M H P, Tripodi Armando
EC-JRC, Institute for Reference Materials and Measurements, Geel, Belgium.
Thromb Haemost. 2006 Aug;96(2):210-4.
Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multicentre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationships between these reference materials when all results were included (5% significance level).
凝血活酶的参考物质可从世界卫生组织（WHO）和欧盟委员会（EC）获得。参考物质的长期稳定性是一项基本要求，必须进行监测。在1996年至2002年期间监测了两种兔凝血活酶参考物质，即ERM-AD149（EC）和RBT/90（WHO）之间的关系。未检测到随时间的显著趋势。此外，1994年和2005年在多中心研究中（分别为n = 11和n = 9）确定了ERM-AD149与牛凝血活酶参考物质（即OBT/79）之间的关系。当纳入所有结果时（5%显著性水平），这些参考物质之间的关系未观察到显著变化。
