Poller L, Thomson J M, Yee K F
Lancet. 1977 Nov 12;2(8046):1019-22. doi: 10.1016/s0140-6736(77)92910-5.
An international framework for anticoagulant control has been developed based on British Comparative Thomboplastin (B.C.T.) and the model provided by the British system for anticoagulant control. An alternative international system has been proposed, based on lymphilised thromboplastins prepared at the National Institute of Biological Standards and Control, London. Since 1969, stability studies on two of the N.I.B.S.& C. reagents, the primary material 67/40 and the secondary thromboplastin 69/223, have been in progress at the National (U.K.) Reference Laboratory for Anticoagulant Reagents and Control, Manchester. Both the proposed N.I.B.S.&C. reference preparations have deteriorated, while two lyophilised reagents prepared at the National (U.K.) Reference Laboratory have revealed no evidence of instability. In national and international standardisation reliance on B.C.T. should continue.
基于英国比较凝血活酶（B.C.T.）和英国抗凝控制体系提供的模型，已开发出一种国际抗凝控制框架。有人提出了另一种国际体系，该体系基于伦敦国家生物标准与控制研究所制备的冻干凝血活酶。自1969年以来，英国曼彻斯特国家抗凝剂试剂与控制参考实验室一直在对两种N.I.B.S.&C.试剂进行稳定性研究，即主要材料67/40和二级凝血活酶69/223。提议的两种N.I.B.S.&C.参考制剂均已变质，而在英国国家参考实验室制备的两种冻干试剂未显示出不稳定的迹象。在国家和国际标准化中，应继续依赖B.C.T.。
