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SARS-CoV-2 肺炎-受体结合和肺免疫病理学：叙述性综述。

SARS-CoV-2 pneumonia-receptor binding and lung immunopathology: a narrative review.

机构信息

Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av Dr Arnaldo, Número 455, São Paulo, SP, 01246903, Brazil.

Department of Pathology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

出版信息

Crit Care. 2021 Feb 8;25(1):53. doi: 10.1186/s13054-020-03399-z.

DOI:10.1186/s13054-020-03399-z
PMID:33557908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7870126/
Abstract

The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.

摘要

当前 COVID-19 大流行导致数千人死亡，医护人员努力妥善管理感染患者。这篇综述总结了有关 SARS-CoV-2 受体结合动力学和复杂性、肺尸检结果、免疫反应模式、基于证据的免疫反应解释以及 COVID-19 相关高凝状态的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/9390170744d3/13054_2020_3399_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/b99a3519577c/13054_2020_3399_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/28ddacecff27/13054_2020_3399_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/bb53b86999b6/13054_2020_3399_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/fda58e91dfd9/13054_2020_3399_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/b85555c0e870/13054_2020_3399_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/9390170744d3/13054_2020_3399_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/b99a3519577c/13054_2020_3399_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/28ddacecff27/13054_2020_3399_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/bb53b86999b6/13054_2020_3399_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/fda58e91dfd9/13054_2020_3399_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/b85555c0e870/13054_2020_3399_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48e3/7871563/9390170744d3/13054_2020_3399_Fig6_HTML.jpg

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