• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

急性肢体缺血:COVID-19 感染的一种不常见并发症。

Acute limb ischaemia: not an uncommon complication of COVID-19 infection.

机构信息

Sri Krishnasevasharama Hospital, Bangalore, India.

出版信息

Ann R Coll Surg Engl. 2022 Jul;104(7):e211-e215. doi: 10.1308/rcsann.2021.0342. Epub 2022 Apr 21.

DOI:10.1308/rcsann.2021.0342
PMID:35446698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9246543/
Abstract

A new variant of coronavirus (2019-nCoV) causing acute respiratory distress in humans was identified for the first time in 2019, in Wuhan, China. One of the many complications of infection with this coronavirus is hypercoagulopathy, resulting in acute thrombosis; often leading to acute limb ischaemia. Herein, we report 20 cases of COVID-19 with peripheral arterial thrombosis involving either upper or lower limbs. Some patients underwent vascular procedures and most had to undergo amputation at some level. All the cases (=20) were referred to us during the 8-month period June 2020 to March 2021. The most common age group was between 51 and 60 years, of whom 80% were males; all the patients had diabetes. The right lower limb was most affected (50%); 15 patients underwent embolectomy. Twenty-five per cent of patients presented with wet gangrene. One patient with upper limb thrombosis recovered after embolectomy and did not require any amputation. Eighty-five per cent of patients underwent some form of amputation and the mortality rate was 10%. Arterial thrombosis is one complication patients may develop during COVID-19 illness, which may affect the outcome. Patients with comorbid conditions like diabetes are at higher risk of developing arterial thrombosis during COVID-19 infection. Susceptibility to coagulopathy may continue even after patient discharge and it is important that both patients and treating physicians are aware of this limb-threatening complication and seek early medical attention.

摘要

一种新型冠状病毒(2019-nCoV)于 2019 年在中国武汉首次被发现,可导致人类急性呼吸窘迫。这种冠状病毒感染的众多并发症之一是高凝状态,导致急性血栓形成;常导致急性肢体缺血。在此,我们报告了 20 例 COVID-19 合并外周动脉血栓形成的病例,累及上肢或下肢。部分患者接受了血管介入治疗,大多数患者需要进行某种程度的截肢。所有病例(=20)均在 2020 年 6 月至 2021 年 3 月期间转诊至我们处。最常见的年龄组在 51-60 岁之间,其中 80%为男性;所有患者均患有糖尿病。最常见的受累部位是右下肢(50%);15 例行取栓术。25%的患者出现湿性坏疽。1 例上肢血栓形成患者取栓后痊愈,无需截肢。85%的患者接受了某种形式的截肢,死亡率为 10%。动脉血栓形成是 COVID-19 患者可能出现的并发症之一,可能影响患者的预后。合并糖尿病等合并症的患者在 COVID-19 感染期间发生动脉血栓形成的风险更高。即使在患者出院后,仍可能存在易发生凝血病的倾向,患者及其治疗医生都应了解这种危及肢体的并发症,并尽早寻求医疗关注。

相似文献

1
Acute limb ischaemia: not an uncommon complication of COVID-19 infection.急性肢体缺血:COVID-19 感染的一种不常见并发症。
Ann R Coll Surg Engl. 2022 Jul;104(7):e211-e215. doi: 10.1308/rcsann.2021.0342. Epub 2022 Apr 21.
2
3
Unexpected arterial thrombosis and acute limb ischemia in COVID-19 patients. Results from the Ibero-Latin American acute arterial thrombosis registry in COVID-19: (ARTICO-19).COVID-19 患者中意外的动脉血栓形成和急性肢体缺血。来自 COVID-19 中伊比利亚-拉丁美洲急性动脉血栓形成登记处的结果:(ARTICO-19)。
Vascular. 2022 Dec;30(6):1107-1114. doi: 10.1177/17085381211052033. Epub 2021 Dec 4.
4
Arterial Thrombosis and Acute Limb Ischemia as a Complication of COVID-19 Infection.COVID-19 感染的并发症:动脉血栓形成和急性肢体缺血。
Am Surg. 2023 May;89(5):2046-2048. doi: 10.1177/00031348211023416. Epub 2021 May 28.
5
COVID-19-related Peripheral Arterial Thrombosis Treated in a Large Health Maintenance Organization.大型健康维护组织中治疗 COVID-19 相关外周动脉血栓。
Ann Vasc Surg. 2022 Aug;84:6-11. doi: 10.1016/j.avsg.2022.04.024. Epub 2022 Apr 22.
6
Axillary artery thrombosis resulting in upper limb amputation as a COVID-19 sequela.腋动脉血栓形成导致上肢截肢作为 COVID-19 的后遗症。
BMJ Case Rep. 2021 Jan 26;14(1):e240981. doi: 10.1136/bcr-2020-240981.
7
Perioperative outcome of acute lower limb ischaemia on the basis of the national vascular registry. The Finnvasc Study Group.基于国家血管登记处的急性下肢缺血围手术期结果。芬兰血管研究小组。
Eur J Vasc Surg. 1994 Sep;8(5):578-83. doi: 10.1016/s0950-821x(05)80594-8.
8
Perioperative and rehabilitative outcomes after amputation for ischaemic leg gangrene.缺血性腿部坏疽截肢术后的围手术期及康复结局
Ann Acad Med Singap. 2000 Mar;29(2):168-72.
9
Acute upper limb ischemia in a patient with COVID-19.COVID-19 患者的急性上肢缺血。
Hematol Oncol Stem Cell Ther. 2021 Dec;14(4):348-350. doi: 10.1016/j.hemonc.2020.05.001. Epub 2020 May 13.
10
A case of rapidly progressive upper limb ischemic necrosis in a patient with COVID-19.一例 COVID-19 患者的上肢进行性缺血性坏死。
Int J Infect Dis. 2021 May;106:401-404. doi: 10.1016/j.ijid.2021.04.023. Epub 2021 Apr 20.

本文引用的文献

1
SARS-CoV-2 pneumonia-receptor binding and lung immunopathology: a narrative review.SARS-CoV-2 肺炎-受体结合和肺免疫病理学:叙述性综述。
Crit Care. 2021 Feb 8;25(1):53. doi: 10.1186/s13054-020-03399-z.
2
Endothelial dysfunction in COVID-19: Current findings and therapeutic implications.COVID-19 中的血管内皮功能障碍:当前研究结果及治疗意义。
Atherosclerosis. 2020 Dec;314:58-62. doi: 10.1016/j.atherosclerosis.2020.10.014. Epub 2020 Oct 14.
3
Septic Embolism in a Patient with Infective Endocarditis and COVID-19.一名感染性心内膜炎合并新冠肺炎患者的脓毒性栓塞
Am J Trop Med Hyg. 2020 Dec;103(6):2160-2161. doi: 10.4269/ajtmh.20-1133. Epub 2020 Oct 16.
4
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19.SARS-CoV-2 病理生理学及其临床意义:COVID-19 药物治疗管理的综合概述。
Food Chem Toxicol. 2020 Dec;146:111769. doi: 10.1016/j.fct.2020.111769. Epub 2020 Sep 30.
5
COVID-19 Infection and Arterial Thrombosis: Report of Three Cases.新型冠状病毒肺炎感染与动脉血栓形成:三例报告
Ann Vasc Surg. 2021 Jan;70:314-317. doi: 10.1016/j.avsg.2020.08.115. Epub 2020 Sep 2.
6
The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management.新型冠状病毒肺炎中的高凝状态:发生率、病理生理学和管理。
Thromb Res. 2020 Oct;194:101-115. doi: 10.1016/j.thromres.2020.06.029. Epub 2020 Jun 20.
7
Lower-extremity Arterial Thrombosis Associated with COVID-19 Is Characterized by Greater Thrombus Burden and Increased Rate of Amputation and Death.与 COVID-19 相关的下肢动脉血栓形成的特点是血栓负荷更大,以及更高的截肢和死亡率。
Radiology. 2020 Nov;297(2):E263-E269. doi: 10.1148/radiol.2020202348. Epub 2020 Jul 16.
8
Extrapulmonary manifestations of COVID-19.COVID-19 的肺外表现。
Nat Med. 2020 Jul;26(7):1017-1032. doi: 10.1038/s41591-020-0968-3. Epub 2020 Jul 10.
9
COVID-19 concomitant with infective endocarditis: A case report and review of management.新型冠状病毒肺炎合并感染性心内膜炎:一例病例报告及治疗回顾
Int J Infect Dis. 2020 Sep;98:109-112. doi: 10.1016/j.ijid.2020.06.061. Epub 2020 Jun 20.
10
Antithrombotic Therapies in COVID-19 Disease: a Systematic Review.抗血栓治疗在 COVID-19 疾病中的应用:一项系统评价。
J Gen Intern Med. 2020 Sep;35(9):2698-2706. doi: 10.1007/s11606-020-05906-y. Epub 2020 Jun 17.