克罗恩病回肠-肛管吻合口处的鳞状细胞癌。
Squamous cell carcinoma at the site of ileo-anal pouch in Crohn's disease.
机构信息
Gastroenterology, London North West University Healthcare NHS Trust, Harrow, London, UK
Gastroenterology, London North West University Healthcare NHS Trust, Harrow, London, UK.
出版信息
BMJ Case Rep. 2021 Feb 8;14(2):e237438. doi: 10.1136/bcr-2020-237438.
Few cases of pouch-related cancers have been reported in inflammatory bowel disease, and squamous cell carcinoma (SCC) is very rare. We have reviewed the published literature searching the online databases PubMed and Medline. Since 1979, there have been eight cases of SCC developing after restorative proctocolectomy in ulcerative colitis. To date, there have been no reported cases of SCC of the ileo-anal pouch in Crohn's disease. We present the case of a 59-year-old woman who underwent colectomy with ileal pouch-anal anastomosis for Crohn's disease during the 1990s. The patient was noted to be anaemic and was experiencing significant weight loss with poor pouch function in 2019. Endoscopy with histology and radiological investigation revealed the presence of SCC of the pouch. This was subsequently treated with surgical therapy and chemoradiotherapy.
炎性肠病相关的 pouch 相关性癌症病例较少，鳞状细胞癌（SCC）则更为罕见。我们检索了在线数据库 PubMed 和 Medline 中的已发表文献。自 1979 年以来，溃疡性结肠炎的直肠结肠切除术（restorative proctocolectomy）后已有 8 例 SCC 发生。迄今为止，尚无克罗恩病的回肠肛管 pouch SCC 报道。我们报告了一例 59 岁女性的病例，该患者在 20 世纪 90 年代因克罗恩病接受结肠切除术和回肠袋肛管吻合术。患者出现贫血，并伴有显著的体重减轻和 pouch 功能不良。内镜检查和组织学以及影像学检查显示 pouch 存在 SCC。随后采用手术治疗和放化疗进行治疗。
Zotero 插件