Beijing Institute of Radiation Medicine, Beijing Key Laboratory of Radiation Biology (No. BZ0325), Beijing, 100850, China.
Department of Biomedical Engineering, Peking University Third Hospital, Beijing, 100083, China.
Sci Rep. 2021 Feb 8;11(1):2883. doi: 10.1038/s41598-021-82462-3.
For the purpose of assessing the radiation dose of the victims involved in the nuclear emergency or radiation accident, a new type of X-band EPR resonant cavity for in vivo fingernail EPR dosimetry was designed and a homemade EPR spectrometer for in vivo fingernail detection was constructed. The microwave resonant mode of the cavity was rectangular TE101, and there was a narrow aperture for fingernail detection opened on the cavity's wall at the position of high detection sensitivity. The DPPH dot sample and the fingernail samples were measured based on the in vivo fingernail EPR spectrometer. The measurements of the DPPH dot sample verified the preliminary functional applicable of the EPR spectrometer and illustrated the microwave power and modulation response features. The fingernails after irradiation by gamma-ray were measured and the radiation-induced signal was acquired. The results indicated that the cavity and the in vivo EPR dosimeter instrument was able to detect the radiation-induced signal in irradiated fingernail, and preliminarily verified the basic function of the instrument and its potential for emergency dose estimate after a radiation accident.
为了评估核紧急情况或辐射事故中涉及的受害者的辐射剂量，设计了一种新型 X 波段电子顺磁共振（EPR）共振腔，用于体内指甲 EPR 剂量测定，并构建了一台用于体内指甲检测的自制 EPR 光谱仪。该腔的微波共振模式为矩形 TE101，在具有高检测灵敏度的位置的腔壁上开有用于指甲检测的窄孔。基于体内指甲 EPR 光谱仪对 DPPH 点样品和指甲样品进行了测量。DPPH 点样品的测量验证了 EPR 光谱仪的初步功能适用性，并说明了微波功率和调制响应特性。测量了γ射线辐照后的指甲，并获得了辐照诱导信号。结果表明，该腔和体内 EPR 剂量计仪器能够检测辐照指甲中的辐射诱导信号，初步验证了仪器的基本功能及其在辐射事故后进行应急剂量估算的潜力。
