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利用血液检测改变早期癌症检测格局——述评当前方法学和未来前景。

Transforming the landscape of early cancer detection using blood tests-Commentary on current methodologies and future prospects.

机构信息

Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN, USA.

出版信息

Br J Cancer. 2021 Apr;124(9):1475-1477. doi: 10.1038/s41416-020-01223-7. Epub 2021 Feb 9.

DOI:10.1038/s41416-020-01223-7
PMID:33558712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8076196/
Abstract

Early cancer detection should lead to an overall stage shift, less-intensive treatments and better patient outcomes. Current recommended screening programmes are limited to a handful of individual cancers. A multi-cancer early detection test that simultaneously detects and localises multiple cancers could reduce the morbidity and mortality associated with cancer.

摘要

早期癌症检测应该导致整体分期转移、治疗强度降低和患者预后改善。目前推荐的筛查方案仅限于少数几种单一癌症。一种能够同时检测和定位多种癌症的多癌症早期检测测试可以降低与癌症相关的发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4a2/8076196/7b72434c00be/41416_2020_1223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4a2/8076196/7b72434c00be/41416_2020_1223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4a2/8076196/7b72434c00be/41416_2020_1223_Fig1_HTML.jpg

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Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016/j.annonc.2020.02.011. Epub 2020 Mar 30.
3
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test.
基于基因组的早期检测筛查：胃肠道癌症前瞻性试验及新兴策略的文献综述
Cureus. 2024 Sep 7;16(9):e68881. doi: 10.7759/cureus.68881. eCollection 2024 Sep.
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Perspectives on Clinical Adoption Barriers to Blood-Based Multi-Cancer Early Detection Tests across Stakeholders.各利益相关者对基于血液的多癌早期检测测试临床应用障碍的看法。
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