Institute of Biophysics, National Research Council, Genoa, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
J Cell Physiol. 2021 Sep;236(9):6225-6234. doi: 10.1002/jcp.30322. Epub 2021 Feb 8.
Band 3 protein (B3p), anion transporter, allows the HCO /Cl exchange across plasma membrane and plays an important role for erythrocytes homeostasis. In addition, B3p is linked to proteins cytoskeleton, thus contributing to cell shape and deformability, essential to erythrocytes adjustment within narrowest capillaries. Taking into account that erythrocytes are a suitable cell model to investigate the response of the oxidative stress effects, B3p functions, and specifically anion exchange capability, determining the rate constant for SO uptake, has been considered. As, in the latter years, rising attention has been addressed to membrane transport system, and particularly to this protein, the present mini-review has been conceived to report the most recent knowledge about B3p, with specific regard to its functions in oxidative stress conditions, including oxidative stress-related diseases.
带 3 蛋白（B3p）是一种阴离子转运蛋白，允许 HCO 3-/Cl-在质膜之间交换，对红细胞的内环境稳定起着重要作用。此外，B3p 与细胞骨架蛋白相连，有助于细胞的形状和变形性，这对红细胞在最狭窄的毛细血管内的调节至关重要。考虑到红细胞是研究氧化应激影响、B3p 功能（特别是阴离子交换能力）的合适细胞模型，因此考虑测定 SO 摄取的速率常数。近年来，人们对膜转运系统，特别是对这种蛋白质的关注度不断提高，因此本综述旨在报告关于 B3p 的最新知识，特别关注其在氧化应激条件下的功能，包括与氧化应激相关的疾病。
