在 COVID-19 大流行期间怀孕：对胎盘各方面的影响。
Being pregnant in the COVID-19 pandemic: Effects on the placenta in all aspects.
机构信息
Department of Histology and Embryology, Gazi University, Institute of Health Sciences, Ankara, Turkey.
出版信息
J Med Virol. 2021 May;93(5):2769-2773. doi: 10.1002/jmv.26857. Epub 2021 Feb 15.
Abstract
The coronavirus disease 2019 (COVID-19), which had spread to the world from Wuhan (China) in late December, was announced as a pandemic by the World Health Organization in March 2020. In addition to acute respiratory syndrome symptoms, this virus also affects nonrespiratory organs, according to existing data. ACE2 and TMPRSS2, which play a critical role in the entrance of SARS-COV-2 into the cell, are coexpressed in placental development stages, so the placenta also carries a risk for this virus. Many studies have shown that this virus causes some histopathological changes in the placenta. The vertical transmission of the virus is not yet clear, but available data have shown that the indirect effects of the virus can be seen on the fetus. This article focuses on revealing the effects of the virus on the placenta in all aspects.
摘要
2019 年冠状病毒病（COVID-19）于 12 月下旬从中国武汉蔓延至全球，世界卫生组织于 2020 年 3 月宣布其为大流行。根据现有数据，这种病毒除了有急性呼吸系统综合征症状外，还会影响非呼吸系统器官。ACE2 和 TMPRSS2 在 SARS-COV-2 进入细胞的过程中发挥着关键作用，它们在胎盘发育阶段共同表达，因此胎盘也存在这种病毒感染的风险。许多研究表明，这种病毒会导致胎盘发生一些组织病理学变化。病毒的垂直传播尚不清楚，但现有数据表明，病毒对胎儿有间接影响。本文重点从各个方面揭示病毒对胎盘的影响。
相似文献
1
Being pregnant in the COVID-19 pandemic: Effects on the placenta in all aspects.在 COVID-19 大流行期间怀孕：对胎盘各方面的影响。
J Med Virol. 2021 May;93(5):2769-2773. doi: 10.1002/jmv.26857. Epub 2021 Feb 15.
2
Placental Expression of ACE2 and TMPRSS2 in Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Are Placental Defenses Mediated by Fetal Sex?母体严重急性呼吸综合征冠状病毒 2 感染中胎盘 ACE2 和 TMPRSS2 的表达：胎盘防御是否受胎儿性别影响？
J Infect Dis. 2021 Dec 8;224(Suppl 6):S647-S659. doi: 10.1093/infdis/jiab335.
3
Single-cell expression profiles of and reveals potential vertical transmission and fetus infection of SARS-CoV-2.和的单细胞表达谱揭示了SARS-CoV-2潜在的垂直传播和胎儿感染。 （注：原文中“and”前后内容缺失，翻译可能不完全准确，需结合完整原文理解）
Aging (Albany NY). 2020 Oct 26;12(20):19880-19897. doi: 10.18632/aging.104015.
4
Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin.人胎盘滋养层细胞表达 SARS-CoV-2 进入因子 ACE2、TMPRSS2 和 Furin。
mSphere. 2021 Apr 14;6(2):e00250-21. doi: 10.1128/mSphere.00250-21.
5
Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta.单细胞 RNA 表达谱分析 SARS-CoV-2 相关 ACE2 和 TMPRSS2 在人滋养层和胎盘。
Ultrasound Obstet Gynecol. 2021 Feb;57(2):248-256. doi: 10.1002/uog.22186.
6
COVID-19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection.新型冠状病毒肺炎与垂直传播：评估人类胎儿和胎盘中 ACE2/TMPRSS2 的表达，以评估 SARS-CoV-2 感染的风险。
BJOG. 2022 Jan;129(2):256-266. doi: 10.1111/1471-0528.16974. Epub 2021 Nov 18.
7
Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns.子宫内严重急性呼吸综合征冠状病毒2（SARS-CoV-2）垂直传播的评估：9名孕妇及其新生儿。
Placenta. 2021 Aug;111:91-96. doi: 10.1016/j.placenta.2021.06.007. Epub 2021 Jun 16.
8
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.在早产或子痫前期妊娠中，胎盘及母胎界面中严重急性呼吸综合征冠状病毒 2 细胞进入基因、血管紧张素转换酶 2 和跨膜丝氨酸蛋白酶 2 的表达。
Am J Obstet Gynecol. 2021 Mar;224(3):298.e1-298.e8. doi: 10.1016/j.ajog.2020.08.055. Epub 2020 Aug 25.
9
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility.ACE2 在妊娠中的作用及其对 COVID-19 易感性的潜在影响。
Clin Sci (Lond). 2021 Aug 13;135(15):1805-1824. doi: 10.1042/CS20210284.
10
Severe Acute Respiratory Syndrome Coronavirus 2 ACE2 and TMPRSS2 Receptor Protein Expression Patterns Throughout Gestation.严重急性呼吸综合征冠状病毒 2 血管紧张素转换酶 2 和跨膜丝氨酸蛋白酶 2 受体蛋白在整个孕期的表达模式。
J Infect Dis. 2021 Dec 8;224(Supplement_6):S642-S646. doi: 10.1093/infdis/jiab164.
引用本文的文献
1
The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations.新冠病毒对南非孕妇胎盘功能的影响：亲吻素表达以及血管和炎症改变的研究
Histochem Cell Biol. 2025 May 5;163(1):49. doi: 10.1007/s00418-025-02381-6.
2
Effect of COVID-19 Infection During Pregnancy on the Plasma/Extracellular Vesicles Pro-Inflammatory Cytokine Profile.孕期感染新型冠状病毒肺炎对血浆/细胞外囊泡促炎细胞因子谱的影响。
Am J Reprod Immunol. 2025 Apr;93(4):e70071. doi: 10.1111/aji.70071.
3
PostCOVID-19 Impact on Perinatal Outcomes.新冠疫情后对围产期结局的影响。
Diagnostics (Basel). 2024 Dec 29;15(1):57. doi: 10.3390/diagnostics15010057.
4
Global Transcriptomic Analysis of Placentas from Women with Gestational SARS-CoV-2 Infection during the Third Trimester of Pregnancy.全球范围内妊娠晚期感染 SARS-CoV-2 的孕妇胎盘的转录组分析。
Int J Mol Sci. 2024 Jan 28;25(3):1608. doi: 10.3390/ijms25031608.
5
Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns.感染和未感染SARS-CoV-2的孕妇NT-proBNP水平的变化：对新生儿的影响
Biomedicines. 2023 Nov 2;11(11):2964. doi: 10.3390/biomedicines11112964.
6
Machine Learning-Based Approach to Predict Intrauterine Growth Restriction.基于机器学习的预测胎儿生长受限的方法。
Cureus. 2023 Jul 6;15(7):e41448. doi: 10.7759/cureus.41448. eCollection 2023 Jul.
7
Navigation of Knowledge: the Impact of COVID-19 on Pregnancy-a Bibliometric Analysis.导航知识：COVID-19 对妊娠的影响——文献计量分析。
Reprod Sci. 2023 Dec;30(12):3548-3562. doi: 10.1007/s43032-023-01312-x. Epub 2023 Jul 24.
8
Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil.妊娠期急性呼吸窘迫导致的胎儿死亡：巴西巴伊亚州的一项基于人群的队列研究。
BMC Pregnancy Childbirth. 2023 May 5;23(1):320. doi: 10.1186/s12884-023-05601-w.
9
SARS-CoV-2 Infection during Pregnancy and Histological Alterations in the Placenta.妊娠期新型冠状病毒2型感染与胎盘组织学改变
Diagnostics (Basel). 2022 Sep 19;12(9):2258. doi: 10.3390/diagnostics12092258.
10
Decreased fetal cardiac output in pregnant women with severe SARS-Cov-2 infection.孕妇严重感染 SARS-CoV-2 可导致胎儿心输出量减少。
Echocardiography. 2022 Jun;39(6):803-810. doi: 10.1111/echo.15367. Epub 2022 May 20.
本文引用的文献
1
Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women.SARS-CoV-2 阳性孕妇的胎盘三期末病理学。
Fetal Pediatr Pathol. 2022 Jun;41(3):403-412. doi: 10.1080/15513815.2020.1828517. Epub 2020 Oct 12.
2
SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancy.整个孕期胎盘组织中严重急性呼吸综合征冠状病毒2血管紧张素转换酶受体检测
Clin Microbiol Infect. 2021 Mar;27(3):489-490. doi: 10.1016/j.cmi.2020.09.049. Epub 2020 Oct 3.
3
Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019.胎盘来源细胞疗法治疗2019冠状病毒病所致呼吸衰竭患者
Crit Care Explor. 2020 Sep 15;2(9):e0207. doi: 10.1097/CCE.0000000000000207. eCollection 2020 Sep.
4
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2.单细胞RNA测序鉴定出人类胎盘中高表达驱动SARS-CoV-2发病机制因子的细胞亚群。
Front Cell Dev Biol. 2020 Aug 19;8:783. doi: 10.3389/fcell.2020.00783. eCollection 2020.
5
Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion.胎盘病理学在 SARS-CoV-2 感染期间和之后的发现：绒毛膜炎和灌注不良的特征。
Pathobiology. 2021;88(1):69-77. doi: 10.1159/000511324. Epub 2020 Sep 18.
6
Pregnancy and COVID-19: management and challenges.妊娠与新型冠状病毒肺炎：管理与挑战
Rev Inst Med Trop Sao Paulo. 2020;62:e62. doi: 10.1590/s1678-9946202062062. Epub 2020 Aug 31.
7
The interference of COVID-19 in the male reproductive system: Important questions and the future of assisted reproduction techniques.新冠病毒对男性生殖系统的影响：重要问题与辅助生殖技术的未来
Clinics (Sao Paulo). 2020;75:e2183. doi: 10.6061/clinics/2020/e2183. Epub 2020 Aug 26.
8
Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads.在 15 对 COVID-19 阳性母婴二联体的胎盘绒毛中，SARS-CoV-2 刺突糖蛋白和 ACE2 与 TMPRSS2 的定位一致，且 TMPRSS2 占优势。
Placenta. 2020 Oct;100:69-74. doi: 10.1016/j.placenta.2020.08.015. Epub 2020 Aug 25.
9
COVID-19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy.妊娠期 COVID-19：胎心监护不令人满意、胎盘病理和凝血功能障碍。
Ultrasound Obstet Gynecol. 2020 Nov;56(5):773-776. doi: 10.1002/uog.22189. Epub 2020 Oct 19.
10
Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta.单细胞 RNA 表达谱分析 SARS-CoV-2 相关 ACE2 和 TMPRSS2 在人滋养层和胎盘。
Ultrasound Obstet Gynecol. 2021 Feb;57(2):248-256. doi: 10.1002/uog.22186.
Zotero 插件