Department of Histology and Embryology, Gazi University, Institute of Health Sciences, Ankara, Turkey.
J Med Virol. 2021 May;93(5):2769-2773. doi: 10.1002/jmv.26857. Epub 2021 Feb 15.
The coronavirus disease 2019 (COVID-19), which had spread to the world from Wuhan (China) in late December, was announced as a pandemic by the World Health Organization in March 2020. In addition to acute respiratory syndrome symptoms, this virus also affects nonrespiratory organs, according to existing data. ACE2 and TMPRSS2, which play a critical role in the entrance of SARS-COV-2 into the cell, are coexpressed in placental development stages, so the placenta also carries a risk for this virus. Many studies have shown that this virus causes some histopathological changes in the placenta. The vertical transmission of the virus is not yet clear, but available data have shown that the indirect effects of the virus can be seen on the fetus. This article focuses on revealing the effects of the virus on the placenta in all aspects.
2019 年冠状病毒病（COVID-19）于 12 月下旬从中国武汉蔓延至全球，世界卫生组织于 2020 年 3 月宣布其为大流行。根据现有数据，这种病毒除了有急性呼吸系统综合征症状外，还会影响非呼吸系统器官。ACE2 和 TMPRSS2 在 SARS-COV-2 进入细胞的过程中发挥着关键作用，它们在胎盘发育阶段共同表达，因此胎盘也存在这种病毒感染的风险。许多研究表明，这种病毒会导致胎盘发生一些组织病理学变化。病毒的垂直传播尚不清楚，但现有数据表明，病毒对胎儿有间接影响。本文重点从各个方面揭示病毒对胎盘的影响。
