Centre for Human Brain Health, University of Birmingham, UK; School of Psychology, University of Birmingham, UK.
School of Psychology, University of Birmingham, UK.
Sleep Med Rev. 2021 Jun;57:101416. doi: 10.1016/j.smrv.2021.101416. Epub 2021 Jan 19.
This systematic review and meta-analysis aims to assess and quantify putative differences in sleep architecture, sleep efficiency, sleep timing and broadly-defined sleep difficulties between children with and without epilepsy. Databases were searched systematically, and studies identified in PubMed, EMBASE, PsychINFO and Medline. The meta-analysis included 19 studies comparing a total of 901 children with epilepsy to 1470 healthy children. Relative to healthy children, children with epilepsy experienced reduced sleep time, sleeping on average 34 mins less across self-report, actigraphy, 24-h video-EEG and polysomnography measures. They had more sleep difficulties specifically in the domains of night waking, parasomnias and sleep disordered breathing. The analysis also revealed a significantly increased percentage of N2 sleep and decreased sleep efficiency in children with epilepsy compared to healthy children. These results illustrate that children with epilepsy are vulnerable to more sleep difficulties compared to healthy children. This suggests that screening for sleep difficulties should be an integral part in a diagnosis of epilepsy to ensure that clinically relevant sleep difficulties are identified and treated. Such an approach may ultimately aid in the development of treatment strategies which can contribute to improvements in both developmental and diagnostic outcomes for children with epilepsy.
本系统评价和荟萃分析旨在评估和量化患有癫痫和无癫痫儿童之间在睡眠结构、睡眠效率、睡眠时间和广义睡眠困难方面的潜在差异。系统地搜索了数据库，并在 PubMed、EMBASE、PsychINFO 和 Medline 中确定了研究。荟萃分析包括 19 项研究，共比较了 901 名癫痫儿童和 1470 名健康儿童。与健康儿童相比，癫痫儿童的睡眠时间减少，自我报告、活动记录仪、24 小时视频脑电图和多导睡眠图测量平均每晚少 34 分钟。他们在夜间觉醒、睡眠障碍和呼吸障碍等方面的睡眠困难更为明显。分析还显示，与健康儿童相比，癫痫儿童的 N2 睡眠时间百分比显著增加，睡眠效率降低。这些结果表明，与健康儿童相比，癫痫儿童更容易出现睡眠困难。这表明，在癫痫诊断中，筛查睡眠困难应成为一个重要组成部分，以确保发现和治疗临床相关的睡眠困难。这种方法最终可能有助于制定治疗策略，这有助于改善癫痫儿童的发育和诊断结果。
