Rysz Jacek, Franczyk Beata, Kujawski Krzysztof, Sacewicz-Hofman Izabela, Ciałkowska-Rysz Aleksanda, Gluba-Brzózka Anna
Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, Poland.
Department of Molecular Cell Mechanisms, Medical University of Lodz, 90-549 Lodz, Poland.
Pharmaceutics. 2021 Feb 6;13(2):231. doi: 10.3390/pharmaceutics13020231.
Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.
慢性肾脏病（CKD）是一个全球性的健康问题，其患病率在持续上升。CKD的病理生理学很复杂，尚未完全阐明。然而，氧化应激升高被认为在该疾病的发展中起着至关重要的作用。CKD也被认为是一种炎症性疾病，其中尿毒症毒素参与了炎症环境的发展。健康、均衡的饮食有助于维持良好的健康状态，因为它有助于降低包括慢性肾脏病、糖尿病和高血压在内的慢性疾病的发生风险。大量研究表明，包括脂肪酸、纤维等功能性分子和营养物质，以及姜黄素、甜菊糖苷和白藜芦醇等营养保健品，不仅对促炎和抗炎途径有有益作用，而且对肠道黏膜也有作用。营养保健品因其对人体潜在的有利生理作用及其安全性，最近引起了极大关注。本综述介绍了一些营养保健品，食用这些营养保健品可能对肾脏疾病以及心血管疾病的发生和发展产生有益影响。
