UKH Linz der AUVA, HLMedConsult, Zehetlandweg 7, A-4060 Leonding, Austria.
Klinik für Orthopädie, Unfallchirurgie und Sporttraumatologie, Zentrum für Schwerbrandverletzte, Marienhospital Stuttgart, Böheimstraße 37, 70199 Stuttgart, Germany.
Medicina (Kaunas). 2021 Feb 5;57(2):143. doi: 10.3390/medicina57020143.
Successful research and development cooperation between a textile research institute, the German Federal Ministry of Education and Research via the Center for Biomaterials and Organ Substitutes, the University of Tübingen, and the Burn Center of Marienhospital, Stuttgart, Germany, led to the development of a fully synthetic resorbable temporary epidermal skin substitute for the treatment of burns, burn-like syndromes, donor areas, and chronic wounds. This article describes the demands of the product and the steps that were taken to meet these requirements. The material choice was based on the degradation and full resorption of polylactides to lactic acid and its salts. The structure and morphology of the physical, biological, and degradation properties were selected to increase the angiogenetic abilities, fibroblasts, and extracellular matrix generation. Water vapor permeability and plasticity were adapted for clinical use. The available scientific literature was screened for the use of this product. A clinical application demonstrated pain relief paired with a reduced workload, fast wound healing with a low infection rate, and good cosmetic results. A better understanding of the product's degradation process explained the reduction in systemic oxidative stress shown in clinical investigations compared to other dressings, positively affecting wound healing time and reducing the total area requiring skin grafts. Today, the product is in clinical use in 37 countries. This article describes its development, the indications for product growth over time, and the scientific foundation of treatments.
纺织研究所、德国联邦教育研究部通过生物材料和器官替代物中心、图宾根大学以及德国斯图加特玛丽亚医院烧伤中心之间的成功研究与开发合作，开发出了一种完全合成的可吸收临时表皮皮肤替代物，用于治疗烧伤、类似烧伤的综合征、供体部位和慢性伤口。本文描述了产品的需求以及为满足这些要求而采取的步骤。材料选择基于聚乳酸的降解和完全吸收为乳酸及其盐。选择结构和形态以提高血管生成能力、成纤维细胞和细胞外基质生成。水蒸气透过率和可塑性适应临床使用。筛选了可用的科学文献，以了解该产品的用途。临床应用表明，该产品具有减轻疼痛、减少工作量、快速愈合伤口、感染率低以及良好的美容效果。对产品降解过程的更好理解解释了与其他敷料相比，临床研究中系统性氧化应激的降低，这对伤口愈合时间产生了积极影响，并减少了需要植皮的总面积。如今，该产品在 37 个国家的临床应用中。本文描述了它的发展、产品随时间推移的适应证以及治疗的科学基础。
