Uhlig C, Rapp M, Hartmann B, Hierlemann H, Planck H, Dittel K-K
Klinik für Unfallchirurgie, Marienhospital, Boeheimstrasse 37, 70199 Stuttgart, Germany.
Burns. 2007 Mar;33(2):221-9. doi: 10.1016/j.burns.2006.04.024. Epub 2006 Nov 2.
Autologous split skin grafts are the most reliable method for closing third degree burns. Under this scheme, donor sites as well as second degree burns under conservative treatment, however, would benefit from rapid wound closure. For this treatment, biological as well as synthetic materials are available. For the improvement of these materials, primary goals are pain reduction and easy handling in the absence of biological risk. From a synthetic copolymer mainly based on DL-lactic acid a new skin substitute was developed, marketed as Suprathel. Within the scope of a bicentric study Suprathel was compared versus paraffin gauze intraindividually applied on split skin donor sites. Wound pain was measured on the Visual Pain Analog Scale over a period of 10 days as the critical criterion. Accordingly Suprathel versus Omiderm were compared on second degree burns (degree 2a, partial thickness burns). In both study parts, Suprathel significantly reduced pain. Its easy handling was superior compared to other materials. The Suprathel membrane adhered rapidly to the wound thus protecting against infections and promoting wound healing. No allergic reactions were observed. The ability of the material to resorb ensured pain-free removal after complete healing of the wound.
自体断层皮片移植是闭合三度烧伤创面最可靠的方法。然而，在该方案下，供皮区以及保守治疗的二度烧伤创面将受益于快速伤口闭合。对于这种治疗，有生物材料和合成材料可供选择。为了改进这些材料，主要目标是减轻疼痛以及在无生物风险的情况下易于操作。基于一种主要由DL-乳酸组成的合成共聚物，研发出了一种新型皮肤替代物，商品名为Suprathel。在一项双中心研究中，将Suprathel与单独应用于断层皮供皮区的石蜡纱布进行了个体内比较。以在10天内通过视觉疼痛模拟量表测量的伤口疼痛作为关键标准。相应地，在二度烧伤（2a度，部分厚度烧伤）创面将Suprathel与Omiderm进行了比较。在两项研究中，Suprathel均显著减轻了疼痛。与其他材料相比，其易于操作的优势明显。Suprathel膜能迅速粘附于伤口，从而预防感染并促进伤口愈合。未观察到过敏反应。该材料的可吸收性确保了伤口完全愈合后可无痛移除。
