Inci Melisa Guelhan, Richter Rolf, Heise Kathrin, Dukatz Ricarda, Woopen Hannah, Sehouli Jalid
Department of Gynecology with Center for Oncological Surgery, European Competence Center for Ovarian Cancer, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany.
Cancers (Basel). 2021 Feb 5;13(4):631. doi: 10.3390/cancers13040631.
The aim of this analysis was to evaluate the health-related quality of life (HR-QoL) in patients with ovarian cancer using a patient-reported outcome (PRO) based questionnaire and to compare it to the healthy female population in Germany and to other ovarian cancer patients worldwide. Additionally, we looked for differences in the HR-QoL with respect to the patients' ages in our cohort.
The HR-QoL for 155 enrolled patients with ovarian cancer was assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) prior to surgery and then compared with 501 healthy females in Germany, as well as to the previously published European Organization for Research and Treatment of Cancer (EORTC) reference data for 917 patients with ovarian cancer worldwide. Moreover, we grouped our cohort by ages <65 and >65 years and analyzed them for further differences. To identify the differences, T-tests were applied.
Overall, 155 patients were enrolled, and 126 patients had advanced-stage ovarian cancer (FIGO III-IV) (82.4%). Fifty-five (36%) patients were >65 years. Except for the physical functioning scale, all other domains of the functioning scales were significantly lower in our patients with ovarian cancer than in the healthy female population. The emotional (50 points versus 60 points, = 0.02), cognitive (76 points versus 88 points, = 0.005), and social functioning scales (68 points versus 81 points, = 0.006) were lower in the younger subgroup. Further, the younger subgroup exhibited significantly more fatigue (40 points versus 29 points, = 0.03) and financial difficulties (20 points versus 2 points, < 0.001) than the older subgroup.
Interestingly, the patients with ovarian cancer had no significant differences in the physical functioning scale when compared with the healthy women. In contrast, the patients, especially in the younger group, needed special support for the emotional and social areas of their daily lives.
本分析的目的是使用基于患者报告结局（PRO）的问卷评估卵巢癌患者的健康相关生活质量（HR-QoL），并将其与德国健康女性人群以及全球其他卵巢癌患者进行比较。此外，我们在我们的队列中寻找HR-QoL在患者年龄方面的差异。
155名入组的卵巢癌患者的HR-QoL在手术前通过欧洲癌症研究与治疗组织生活质量问卷（EORTC QLQ-C30）进行评估，然后与德国的501名健康女性以及先前发表的欧洲癌症研究与治疗组织（EORTC）关于全球917名卵巢癌患者的参考数据进行比较。此外，我们将队列按年龄<65岁和>65岁分组，并分析进一步的差异。为了确定差异，应用了t检验。
总体而言，155名患者入组，126名患者患有晚期卵巢癌（FIGO III-IV期）（82.4%）。55名（36%）患者年龄>65岁。除身体功能量表外，我们的卵巢癌患者功能量表的所有其他领域均显著低于健康女性人群。年轻亚组的情绪（50分对60分，P = 0.02）、认知（76分对88分，P = 0.005）和社会功能量表（68分对81分，P = 0.006）较低。此外，年轻亚组比老年亚组表现出明显更多的疲劳（40分对29分，P = 0.03）和经济困难（20分对2分，P < 0.001）。
有趣的是，与健康女性相比，卵巢癌患者在身体功能量表上没有显著差异。相比之下，患者，尤其是年轻组患者，在日常生活的情感和社会领域需要特殊支持。
