Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Int J Mol Sci. 2021 Apr 19;22(8):4210. doi: 10.3390/ijms22084210.
The increase in the incidence of cardiovascular diseases (CVDs) and kidney disease has stimulated research for strategies that could prevent, rather than just treat, both interconnected disorders. Resveratrol, a polyphenolic compound with pleiotropic biofunctions, has shown health benefits. Emerging epidemiological data supports that early life environmental insults are regarded as increased risks of developing CVDs and kidney disease in adulthood. Conversely, both disorders could be reversed or postponed by shifting interventions from adulthood to earlier stage by so-called reprogramming. The purpose of this review is first to highlight current epidemiological studies linking cardiovascular and renal programming to resulting CVD and kidney disease of developmental origins. This will be followed by a summary of how resveratrol could exert a positive influence on CVDs and kidney disease. This review also presents an overview of the evidence documenting resveratrol as a reprogramming agent to protect against CVD and kidney disease of developmental origins from animal studies and to outline the advances in understanding the underlying molecular mechanisms. Overall, this review reveals the need for future research to further clarify the reprogramming effects of resveratrol before clinical translation.
心血管疾病 (CVDs) 和肾脏疾病发病率的增加，刺激了人们研究预防这两种相互关联疾病的策略，而不仅仅是治疗。白藜芦醇是一种具有多种生物功能的多酚化合物，已显示出对健康有益。新兴的流行病学数据支持这样一种观点，即早期生活环境的损害被认为是成年后患 CVD 和肾脏疾病的风险增加。相反，通过将干预措施从成年期转移到早期阶段（即所谓的重编程），这两种疾病都可以得到逆转或推迟。本综述的目的首先是强调当前将心血管和肾脏编程与发育起源的 CVD 和肾脏疾病联系起来的流行病学研究。其次，将总结白藜芦醇如何对 CVD 和肾脏疾病产生积极影响。本综述还概述了有证据表明白藜芦醇作为一种重编程剂，可预防动物研究中由发育起源引起的 CVD 和肾脏疾病，并概述了对潜在分子机制的理解的进展。总的来说，本综述揭示了未来研究的必要性，以便在临床转化之前进一步阐明白藜芦醇的重编程作用。
