吸烟与炎症性肠病。一项病例对照研究。
Smoking and inflammatory bowel disease. A case control study.
作者信息
Lindberg E, Tysk C, Andersson K, Järnerot G
机构信息
Department of Medicine, Orebro Medical Center Hospital, Sweden.
出版信息
Gut. 1988 Mar;29(3):352-7. doi: 10.1136/gut.29.3.352.
Abstract
A population case controlled study of smoking habits at the time of diagnosis was done in 260 patients with ulcerative colitis and 144 with Crohn's disease. Smokers had a decreased risk of acquiring ulcerative colitis in comparison with never smokers (relative risk 0.7) which appeared to be dose dependent. In former smokers a rebound effect was seen, especially in former heavy smokers, where the risk was sharply increased (relative risk 4.4). No sex difference was recorded. Smoking doubled the risk of acquiring Crohn's disease without any dose dependent pattern. In former smokers a non-significantly increased risk was observed. This might be caused by a carry over effect after stopping smoking, however, which possibly is reduced by time. No sex difference was seen.
摘要
对260例溃疡性结肠炎患者和144例克罗恩病患者进行了一项关于诊断时吸烟习惯的群体病例对照研究。与从不吸烟者相比，吸烟者患溃疡性结肠炎的风险降低（相对风险为0.7），且似乎存在剂量依赖性。在既往吸烟者中，尤其是既往重度吸烟者，出现了反弹效应，其风险急剧增加（相对风险为4.4）。未记录到性别差异。吸烟使患克罗恩病的风险增加一倍，且无任何剂量依赖模式。在既往吸烟者中，观察到风险有非显著性增加。然而，这可能是戒烟后的残留效应所致，不过随着时间推移这种效应可能会减弱。未观察到性别差异。
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