未结合胆红素和来自光照冈恩大鼠的胆汁会抑制肠道对水和电解质的吸收。
Unconjugated bilirubin and the bile from light exposed Gunn rats inhibit intestinal water and electrolyte absorption.
作者信息
Guandalini S, Fasano A, Albini F, Marchesano G, Nocerino A, De Curtis M, Rubaltelli F F, Pettenazzo A, Rubino A
机构信息
Department of Pediatrics, 2nd School of Medicine, University of Naples, Italy.
出版信息
Gut. 1988 Mar;29(3):366-71. doi: 10.1136/gut.29.3.366.
Jaundiced babies undergoing phototherapy often develop diarrhoea. The cause of it is still uncertain. Increasing evidence supports a role of a secretory mechanism for the diarrhoea. We therefore studied the effects of bile from congenitally jaundiced rats undergoing phototherapy and of unconjugated bilirubin on rat small intestine in vivo and in vitro. Results suggest that: (1) the bile from homozygous Gunn rats under phototherapy has an anti-absorptive effect when tested in the perfused jejunum of normal Wistar rats; (2) unconjugated bilirubin has a dose dependent secretory effect on the intestinal transport of water and electrolytes, when tested in the same system. Alteration of cyclic AMP or cyclic GMP, known intracellular mediators of secretion, was not observed. We conclude that free bilirubin is an intestinal secretagogue acting by an as yet unknown mechanism, that may mediate the secretory type of diarrhoea in jaundiced neonates undergoing phototherapy.
接受光疗的黄疸婴儿常出现腹泻。其病因尚不确定。越来越多的证据支持腹泻存在一种分泌机制。因此，我们研究了接受光疗的先天性黄疸大鼠的胆汁以及未结合胆红素对大鼠小肠的体内和体外作用。结果表明：（1）在正常Wistar大鼠的灌注空肠中进行测试时，光疗下纯合子Gunn大鼠的胆汁具有抗吸收作用；（2）在同一系统中进行测试时，未结合胆红素对水和电解质的肠道转运具有剂量依赖性分泌作用。未观察到已知的细胞内分泌介质环磷酸腺苷（cAMP）或环磷酸鸟苷（cGMP）的改变。我们得出结论，游离胆红素是一种肠道促分泌素，其作用机制尚不清楚，可能介导接受光疗的黄疸新生儿的分泌型腹泻。
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