Fujita Kyoko, Imamura Yutaka, Shinoda Kei, Matsumoto Soiti, Yuzawa Mitsuko
Department of Ophthalmology, Aichi Medical University, Aichi, Japan.
Department of Ophthalmology, Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Japan.
Biomed Hub. 2020 Dec 30;6(1):1-5. doi: 10.1159/000512662. eCollection 2021 Jan-Apr.
To evaluate the fundus autofluorescence (FAF) images 1 year after half-dose photodynamic therapy (hdPDT) for chronic central serous chorioretinopathy (CSC).
Forty-six eyes of 46 consecutive patients with chronic CSC underwent hdPDT. Short wavelength-elicited FAF images and enhanced depth imaging optical coherence tomographic (EDI-OCT) images were recorded before and at 1, 3, 6, 9, and 12 months after the hdPDT. The FAF images at 1 month were compared to those at 12 months after the hdPDT.
The serous retinal detachment (SRD) was resolved in all eyes. The best-corrected visual acuity (BCVA) improved significantly from 0.13 ± 0.28 logarithm of minimum angle of resolution (logMAR) units before to 0.01 ± 0.17 logMAR units at 12 months after the hdPDT ( = 0.001; paired test). The mean choroidal thickness decreased significantly from 365.4 ± 103.0 µm to 284.3 ± 92.5 µm at 12 months ( < 0.001). Abnormal FAF images were present within the irradiated area in all the eyes before the hdPDT. In 5 of 46 eyes, identifiable changes of the FAF images were observed 12 months after hdPDT. None of the eyes had the confluent hypo-FAF type during the follow-up period. Univariate analyses showed that the choroidal thickness before hdPDT correlated significantly with hypo-FAF enlargement ( = 0.005). However, multivariate analyses showed that the association was not significant ( = 0.06).
The progression of the RPE damages occurred in approximately one-tenth of the eyes that underwent hdPDT for chronic CSC. The long-term effect of progression of hypo-FAF on visual functions remains to be determined.
评估半剂量光动力疗法（hdPDT）治疗慢性中心性浆液性脉络膜视网膜病变（CSC）1年后的眼底自发荧光（FAF）图像。
46例连续慢性CSC患者的46只眼接受了hdPDT治疗。在hdPDT治疗前以及治疗后1、3、6、9和12个月记录短波激发的FAF图像和增强深度成像光学相干断层扫描（EDI-OCT）图像。将hdPDT治疗后1个月的FAF图像与12个月后的图像进行比较。
所有眼的浆液性视网膜脱离（SRD）均得到解决。最佳矫正视力（BCVA）从hdPDT治疗前的0.13±0.28最小分辨角对数（logMAR）单位显著提高至治疗后12个月的0.01±0.17 logMAR单位（P = 0.001；配对t检验）。12个月时脉络膜平均厚度从365.4±103.0 µm显著降至284.3±92.5 µm（P < 0.001）。hdPDT治疗前所有眼的照射区域内均存在异常FAF图像。46只眼中有5只在hdPDT治疗12个月后观察到FAF图像有可识别的变化。随访期间无眼出现融合性低自发荧光类型。单因素分析显示hdPDT治疗前的脉络膜厚度与低自发荧光扩大显著相关（P = 0.005）。然而，多因素分析显示该关联不显著（P = 0.06）。
接受hdPDT治疗的慢性CSC患者中约十分之一的眼发生了视网膜色素上皮（RPE）损害进展。低自发荧光进展对视觉功能的长期影响仍有待确定。
