LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear & Throat Hospital, New York, New York, USA.
Ophthalmology. 2011 Apr;118(4):700-5. doi: 10.1016/j.ophtha.2010.08.017. Epub 2010 Nov 5.
To investigate the fundus autofluorescence (FAF) abnormalities in central serous chorioretinopathy (CSC) and evaluate potential correlations with visual acuity.
Retrospective, observational case series.
Four hundred seventy-five eyes of 238 patients with CSC.
Consecutive patients with CSC underwent FAF imaging, as well as routine ophthalmologic examinations. Confluent hypoautofluorescence was defined as a region of absent autofluorescence greater than one fourth of a disk diameter. Granular hypoautofluorescence was defined if there was a grainy or coarse region of decreased fluorescence as compared with normal surrounding areas greater than one fourth of a disc diameter in size. A descending tract was a downward leading swathe of decreased autofluorescence originating from the posterior pole to extend below the inferior arcade.
The pattern and frequency of FAF abnormalities and their correlations with corrected visual acuity.
The mean age of the subjects was 57.1 years (standard deviation, 13.3), and 181 (76.1%) were male. Confluent and granular hypoautofluorescence was detected in the macula of 54 (11.4%) and 300 (63.2%) of 475 eyes, respectively. Descending tracts from the macula were observed in 43 (9.1%) eyes and from the optic disc in 43 (9.1%) eyes. Multiple regression analysis revealed that confluent hypoautofluorescence of the macula, granular hypoautofluorescence of the macula, and increasing age all were independent predictors of decreased visual acuity.
The FAF abnormalities in CSC show multiple distinct patterns and seem to provide functional information.
探讨中心性浆液性脉络膜视网膜病变（CSC）的眼底自发荧光（FAF）异常，并评估其与视力的潜在相关性。
回顾性、观察性病例系列。
238 例 CSC 患者的 475 只眼。
连续的 CSC 患者行 FAF 成像及常规眼科检查。融合性低自发荧光定义为大于 1/4 视盘直径的无自发荧光区域。颗粒状低自发荧光定义为与正常周围区域相比，直径大于 1/4 视盘的荧光减少的颗粒状或粗糙区域。下降束是指从后极开始向下延伸到下方下弓下方的低自发荧光引导带。
FAF 异常的模式和频率及其与矫正视力的相关性。
受试者的平均年龄为 57.1 岁（标准差，13.3），男性 181 例（76.1%）。54 只眼（11.4%）和 300 只眼（63.2%）的黄斑区出现融合性和颗粒状低自发荧光。43 只眼（9.1%）从黄斑区观察到下降束，43 只眼（9.1%）从视盘观察到下降束。多元回归分析显示，黄斑区融合性低自发荧光、黄斑区颗粒状低自发荧光和年龄增加均是视力下降的独立预测因素。
CSC 的 FAF 异常呈现多种不同的模式，似乎提供了功能信息。
