Place D A, Scidmore N C, McArthur W P
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville 32610.
Infect Immun. 1988 May;56(5):1394-8. doi: 10.1128/iai.56.5.1394-1398.1988.
Murine hybridoma cell lines were developed which synthesized monoclonal antibodies against Actinobacillus actinomycetemcomitans-associated antigens. Monoclonal antibodies specific for an antigen(s) common to all A. actinomycetemcomitans isolates tested but not detected on other gram-negative oral plaque microorganisms or other Actinobacillus species were identified. Monoclonal antibodies specific for each serotype group of A. actinomycetemcomitans which did not bind to other Actinobacillus species or oral plaque microorganisms were also identified.
开发了小鼠杂交瘤细胞系，该细胞系可合成针对伴放线放线杆菌相关抗原的单克隆抗体。鉴定出了对所有测试的伴放线放线杆菌分离株共有的一种抗原具有特异性，但在其他革兰氏阴性口腔菌斑微生物或其他放线杆菌属物种上未检测到的单克隆抗体。还鉴定出了对伴放线放线杆菌的每个血清型组具有特异性，且不与其他放线杆菌属物种或口腔菌斑微生物结合的单克隆抗体。
