癌症中的非编码表观转录组。
The non-coding epitranscriptome in cancer.
出版信息
Brief Funct Genomics. 2021 Mar 27;20(2):94-105. doi: 10.1093/bfgp/elab003.
Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes. Modifications of non-coding RNAs are particularly interesting since they can directly affect their structure, stability, interaction and function. Indeed, non-coding RNAs such as tRNA and rRNA are the most modified RNA species in eukaryotic cells. In the last 20 years, new functions of non-coding RNAs have been discovered and their involvement in human disease, including cancer, became clear. In this review, we will present the evidence connecting modifications of different non-coding RNA subtypes and their role in cancer.
生物分子的合成后修饰是调节和优化其功能的有效方法。人类转录组包括已知存在于所有 RNA 亚型中的 100 多种修饰。非编码 RNA 的修饰特别有趣，因为它们可以直接影响它们的结构、稳定性、相互作用和功能。事实上，tRNA 和 rRNA 等非编码 RNA 是真核细胞中修饰最多的 RNA 种类。在过去的 20 年中，非编码 RNA 的新功能被发现，并且它们在包括癌症在内的人类疾病中的作用也变得清晰。在这篇综述中，我们将介绍将不同非编码 RNA 亚型的修饰与其在癌症中的作用联系起来的证据。
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