Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Curr Top Microbiol Immunol. 2023;440:67-86. doi: 10.1007/82_2020_231.
Individuals living in endemic hotspots of Lassa fever have recurrent exposure to Lassa virus (LASV) via spillover from the primary host reservoir Mastomys natalensis. Despite M. natalensis being broadly distributed across sub-Saharan Africa, Lassa fever is only found in West Africa. In recent years, new LASV reservoirs have been identified. Erudition of rodent habitats, reproduction and fecundity, movement patterns, and spatial preferences are essential to institute preventative measures against Lassa fever. Evolutionary insights have also added to our knowledge of closely related mammarenavirus distribution amongst rodents throughout the continent.
生活在拉沙热地方性流行热点地区的个体通过从主要宿主储备鼠（Mastomys natalensis）溢出而反复接触拉沙病毒（LASV）。尽管 Mastomys natalensis 在撒哈拉以南非洲广泛分布，但拉沙热仅在西非发现。近年来，已经确定了新的 LASV 宿主。了解啮齿动物的栖息地、繁殖和生育能力、运动模式和空间偏好对于制定预防拉沙热的措施至关重要。进化见解也增加了我们对非洲大陆啮齿动物中密切相关的 mammarenavirus 分布的了解。
