Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Health Care Center Breza, Breza, Bosnia and Herzegovina.
Rom J Intern Med. 2021 May 8;59(2):180-186. doi: 10.2478/rjim-2020-0044. Print 2021 Jun 1.
Present study was performed to verify red blood cell distribution width-to-platelet ratio (RPR) level in rheumatoid arthritis (RA) patients and to examine its correlation with clinical and biochemical indicators of disease activity status. In this cross-sectional analytical study, 67 patients with RA and 34 age- and gender-matched healthy control subjects were enrolled. Based on the disease activity score 28-ESR (DAS28-ESR), RA patients were divided into subgroups: low disease activity (n = 20), moderate disease activity (n = 22) and high disease activity (n = 25). Laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) concentration, platelet count (PLT), red blood cells count (RBC), red blood cells distribution width (RDW) and fibrinogen concentration. Statistical analyses were carried out using SPSS 13 software. Statistical significance was set at a p-value less than 0.05. There was statistically significant difference (p = 0.006) between RPR in RA patients with different stages of disease activity, with higher values in patients with low disease activity. The RPR showed statistically significant negative correlations with ESR (rho = -0.309; p = 0.012), CRP (rho = -0.421; p = 0.001), swollen joint count - SJC (rho = -0.368; p = 0.002) and tender joint count - TJC (rho = -0.355; p = 0.003), DAS28-ESR (rho = -0.409; p = 0.001), DAS28-CRP (rho = -0.422; p < 0.0005) and Visual analogue scale - VAS (rho = -0.260; p = 0.033) in RA patients. The present study provided evidence that the lower RPR values in RA patients are significantly associated with the disease activity indicators.
本研究旨在验证红细胞分布宽度与血小板比值（RPR）在类风湿关节炎（RA）患者中的水平，并探讨其与疾病活动状态的临床和生化指标的相关性。在这项横断面分析研究中，共纳入 67 例 RA 患者和 34 名年龄和性别匹配的健康对照者。根据疾病活动评分 28-红细胞沉降率（DAS28-ESR），将 RA 患者分为亚组：低疾病活动组（n=20）、中疾病活动组（n=22）和高疾病活动组（n=25）。实验室检查包括红细胞沉降率（ESR）、C 反应蛋白（CRP）浓度、血小板计数（PLT）、红细胞计数（RBC）、红细胞分布宽度（RDW）和纤维蛋白原浓度。统计分析采用 SPSS 13 软件进行。统计学意义设定为 p 值小于 0.05。不同疾病活动阶段的 RA 患者的 RPR 存在统计学差异（p=0.006），低疾病活动组患者的 RPR 值较高。RPR 与 ESR（rho=-0.309；p=0.012）、CRP（rho=-0.421；p=0.001）、肿胀关节计数-SJC（rho=-0.368；p=0.002）、压痛关节计数-TJC（rho=-0.355；p=0.003）、DAS28-ESR（rho=-0.409；p=0.001）、DAS28-CRP（rho=-0.422；p<0.0005）和视觉模拟评分-VAS（rho=-0.260；p=0.033）呈统计学负相关。本研究表明，RA 患者较低的 RPR 值与疾病活动指标显著相关。
