Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
Clinical Pathology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
Reumatol Clin (Engl Ed). 2022 Aug-Sep;18(7):399-405. doi: 10.1016/j.reumae.2021.04.011.
Hemogram parameters have been recently proposed as markers of inflammation in various studies from different parts of the world. Two of these hemogram parameters are red cell distribution width (RDW) and mean platelet volume (MPV).
To evaluate the relation between RDW and MPV with disease activity of rheumatoid arthritis. To assess whether RDW and MPV can be used to follow disease activity in RA patients.
This is an observational cross-sectional study that was carried out on 60 rheumatoid arthritis patients who fulfilled the ACR/EULAR2010 classification criteria of RA attending to Rheumatology and Rehabilitation inpatient and outpatient clinics at Zagazig University Hospitals. All cases were subjected to full history taking, clinical examination, and laboratory investigations; differential complete blood picture (CBC), acute phase reactants (CRP and ESR), rheumatoid factor (RF) and anti-cyclic-citrullinated peptide (anti-CCP) antibodies. Disease activity was measured by disease activity score 28 (DAS28).
The cut-off levels of RDW and MPV were 14.85 and 11.25. Patients with RDW>14.85 had higher Disease Activity Score 28 (DAS28; p=0.0003), ESR (p=0.0001) and CRP (p=0.0001). RDW was positively correlated with disease activity markers (ESR, CRP and DAS28) in rheumatoid arthritis patients. But, DAS28 was not different between patients with MPV>11.25 and <11.25.
RDW was strongly correlated with disease activity. Also, RDW was better than ESR and CRP in detecting RA disease activity. According to these findings we suggest that RDW can be used in clinics to follow disease activity. In addition, RDW is widely available; as it's usually included in routine complete blood picture and there will be no need for further cost.
最近，在来自世界各地的不同研究中，血液学参数已被提出作为炎症的标志物。这两个血液学参数是红细胞分布宽度（RDW）和平均血小板体积（MPV）。
评估 RDW 和 MPV 与类风湿关节炎疾病活动之间的关系。评估 RDW 和 MPV 是否可用于监测 RA 患者的疾病活动。
这是一项观察性横断面研究，在 Zagazig 大学医院的风湿病学和康复住院和门诊诊所就诊的符合 ACR/EULAR2010 类风湿关节炎分类标准的 60 例类风湿关节炎患者中进行。所有病例均接受了详细的病史采集、临床检查和实验室检查；全血细胞计数（CBC）、急性期反应物（CRP 和 ESR）、类风湿因子（RF）和抗环瓜氨酸肽（抗-CCP）抗体的差异。疾病活动通过疾病活动评分 28（DAS28）进行测量。
RDW 和 MPV 的临界值分别为 14.85 和 11.25。RDW>14.85 的患者具有更高的疾病活动评分 28（DAS28；p=0.0003）、ESR（p=0.0001）和 CRP（p=0.0001）。RDW 与类风湿关节炎患者的疾病活动标志物（ESR、CRP 和 DAS28）呈正相关。但是，MPV>11.25 和 <11.25 的患者之间 DAS28 无差异。
RDW 与疾病活动密切相关。此外，RDW 在检测 RA 疾病活动方面优于 ESR 和 CRP。根据这些发现，我们建议 RDW 可用于临床监测疾病活动。此外，RDW 广泛可用；因为它通常包含在常规全血细胞计数中，并且不需要额外的成本。
