Li Jiaqi, Liu Mingzhuo, Hu Yong, Guo Guanghua
Department of Burn, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Corresponding author: Guo Guanghua, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Jan;33(1):118-121. doi: 10.3760/cma.j.cn121430-20200408-00262.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a respiratory disorder with high morbidity and mortality caused by various causes. Exosomes can mediate cell communication through paracrine pathways, transfer proteins, lipids, nucleic acids, etc., and interfere with the biological functions of recipient cells. Various cell-derived exosomes have been reported to play an immunomodulatory role in the ALI/ARDS inflammatory model. This article reviews the mechanism of exosomes involved in immune regulation of ALI/ARDS and possible therapeutic approaches.
急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）是一种由多种原因引起的、具有高发病率和死亡率的呼吸系统疾病。外泌体可以通过旁分泌途径介导细胞间通讯，转运蛋白质、脂质、核酸等，并干扰受体细胞的生物学功能。据报道，各种细胞来源的外泌体在ALI/ARDS炎症模型中发挥免疫调节作用。本文综述了外泌体参与ALI/ARDS免疫调节的机制及可能的治疗方法。
