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外泌体在治疗 ALI/ARDS 中的应用进展。

Advances in the use of exosomes for the treatment of ALI/ARDS.

机构信息

School of Medicine, Nankai University, Tianjin, China.

Center of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

出版信息

Front Immunol. 2022 Aug 9;13:971189. doi: 10.3389/fimmu.2022.971189. eCollection 2022.

DOI:10.3389/fimmu.2022.971189
PMID:36016948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9396740/
Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality. Currently, the primary treatment for ALI/ARDS is mainly symptomatic therapy such as mechanical ventilation and fluid management. Due to the lack of effective treatment strategies, most ALI/ARDS patients face a poor prognosis. The discovery of exosomes has created a promising prospect for the treatment of ALI/ARDS. Exosomes can exert anti-inflammatory effects, inhibit apoptosis, and promote cell regeneration. The microRNA contained in exosomes can participate in intercellular communication and play an immunomodulatory role in ALI/ARDS disease models. This review discusses the possible mechanisms of exosomes in ALI/ARDS to facilitate the development of innovative treatments for ALI/ARDS.

摘要

急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）是一种具有高发病率和死亡率的严重临床综合征。目前，ALI/ARDS 的主要治疗方法主要是对症治疗，如机械通气和液体管理。由于缺乏有效的治疗策略，大多数 ALI/ARDS 患者预后不良。外泌体的发现为 ALI/ARDS 的治疗带来了有希望的前景。外泌体可以发挥抗炎作用，抑制细胞凋亡，促进细胞再生。外泌体中包含的 microRNA 可以参与细胞间通讯，并在 ALI/ARDS 疾病模型中发挥免疫调节作用。本综述讨论了外泌体在 ALI/ARDS 中的可能作用机制，以促进 ALI/ARDS 的创新治疗方法的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/27d0f8e426f5/fimmu-13-971189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/4fc80c536092/fimmu-13-971189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/264c5bf15789/fimmu-13-971189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/27d0f8e426f5/fimmu-13-971189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/4fc80c536092/fimmu-13-971189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/264c5bf15789/fimmu-13-971189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dce/9396740/27d0f8e426f5/fimmu-13-971189-g003.jpg

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