Quan Chao, Wang Mingrui, Chen Huan, Zhang Huali
Sepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan Province 410078, PR China.
Sepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan Province 410078, PR China.
Int Immunopharmacol. 2021 Nov;100:108118. doi: 10.1016/j.intimp.2021.108118. Epub 2021 Sep 1.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), characterized by a large number of inflammatory cell aggregation and alveolar cell damage in pathophysiology, have extremely high morbidity and mortality in critically ill patients. In recent years, more and more studies have found that there are abundant extracellular vesicles (EVs) in animal models and patients with ALI/ARDS, and they play a critical role in the pathogenesis of lung injury. Clarifying the mechanisms of EVs in lung injury is of great significance in the diagnosis and treatment of ALI/ARDS. In this review, we will summarize the recent findings on the roles of EVs derived from different cells in ALI/ARDS, along with the formation, function, and related effects of EVs, and explore their potential clinical application for the diagnosis and treatment of ALI/ARDS.
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）在病理生理学上的特征是大量炎症细胞聚集和肺泡细胞损伤，在重症患者中发病率和死亡率极高。近年来，越来越多的研究发现，在ALI/ARDS动物模型和患者中存在大量细胞外囊泡（EVs），它们在肺损伤的发病机制中起关键作用。阐明EVs在肺损伤中的机制对ALI/ARDS的诊断和治疗具有重要意义。在这篇综述中，我们将总结不同细胞来源的EVs在ALI/ARDS中的作用的最新发现，以及EVs的形成、功能和相关影响，并探讨它们在ALI/ARDS诊断和治疗中的潜在临床应用。
