School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Department of Cardiology, Alfred Health, Melbourne, VIC 3004, Australia.
Int J Environ Res Public Health. 2021 Feb 8;18(4):1587. doi: 10.3390/ijerph18041587.
Little research has examined the effects of high concentration, medium-duration smoke exposure on cardiovascular health. We investigated whether six weeks of exposure to smoke from the 2014 Hazelwood coal mine fire in Victoria (Australia), was associated with long-term clinical or subclinical cardiovascular disease approximately four years later, in adult residents of the towns of Morwell (exposed, = 336) and Sale (unexposed, = 162). The primary outcome was serum high sensitivity (hs) C-reactive protein (CRP). Blood pressure, electrocardiogram, flow mediated dilatation and serum levels of hs-troponin, N-terminal pro B-type natriuretic peptide and lipids were secondary outcomes. There was no significant difference in weighted median hsCRP levels between exposed and unexposed participants (1.9 mg/L vs. 1.6 mg/L, = 0.273). Other outcomes were comparable between the groups. hsCRP was associated in a predictable manner with current smoking, obesity and use of lipid-lowering therapy. Four years after a 6-week coal mine fire, this study found no association between smoke exposure and markers of clinical or subclinical cardiovascular disease in exposed adults.
鲜有研究探讨过高浓度、中时间烟雾暴露对心血管健康的影响。我们调查了大约四年后，居住在莫尔威尔镇（暴露组，n = 336）和赛尔镇（未暴露组，n = 162）的成年居民，暴露于 2014 年维多利亚州黑泽伍德煤矿火灾烟雾长达六周，是否与长期临床或亚临床心血管疾病有关。主要结局指标为血清高敏 C 反应蛋白（hs-CRP）。次要结局指标包括血压、心电图、血流介导的扩张、hs-肌钙蛋白、N 末端 pro B 型利钠肽和血脂水平。暴露组和未暴露组的加权中位数 hs-CRP 水平无显著差异（1.9 mg/L 比 1.6 mg/L，= 0.273）。两组其他结局指标无显著差异。hs-CRP 与当前吸烟、肥胖和使用降脂治疗呈可预测的关联。在煤矿火灾发生六周后的四年，这项研究未发现暴露于烟雾与暴露组成年人的临床或亚临床心血管疾病标志物之间存在关联。
