Sarantis L, Roche D, Psychoyos A
Laboratoire de Physiologie de la Reproduction, CNRS UA 549, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Hum Reprod. 1988 Feb;3(2):251-5. doi: 10.1093/oxfordjournals.humrep.a136688.
In the rat, the period of receptivity for nidation (implantation window) is characterized by specific change of the apical surface of the luminal uterine epithelium, such as the presence of large ectoplasmic projections (pinopodes). Under the conditions of this study, fully developed pinopodes appeared during normal pseudopregnancy on day 5 only. When RU 486 (5 mg/kg s.c.) was given once on day 1, the chronological limits of the appearance of these projections were changed. Fully formed pinopodes were observed on days 6-8 instead of day 5, indicating a displacement and enlargement of the receptive period. This property of the progesterone antagonist could be of clinical interest if it could be used to enlarge the 'implantation window' in women after replacement of in-vitro fertilized eggs.
在大鼠中，着床接受期（着床窗）的特征是子宫腔上皮顶端表面发生特定变化，如出现大的外质突起（微绒毛）。在本研究条件下，仅在正常假孕第5天出现完全发育的微绒毛。当在第1天单次皮下注射RU 486（5毫克/千克）时，这些突起出现的时间界限发生了变化。在第6 - 8天观察到完全形成的微绒毛，而非第5天，这表明接受期发生了位移和延长。如果这种孕酮拮抗剂可用于在体外受精胚胎移植后扩大女性的“着床窗”，那么其这一特性可能具有临床意义。
