Beni-Suef University Faculty of Medicine, Beni-Suef, Egypt.
Minia University Faculty of Medicine, El Maady, Egypt.
Eur J Ophthalmol. 2022 Jan;32(1):436-442. doi: 10.1177/1120672121992960. Epub 2021 Feb 10.
To investigate the effect of chronic smoking on the macula and optic nerve integrity using optical coherence tomography angiography (OCTA).
This prospective, comparative study involved the right eyes of 160 healthy subjects (80 smokers group, and 80 control group). OCTA scanning was performed for all subjects. All macular subfields thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, macular ganglion cell complex (GCC) thickness, superficial and deep macular vessel density, foveal avascular zone (FAZ) area, and the macular outer retina flow area, were measured and analyzed.
The thickness of some macular subfields, inferior GCC, and RNFL was statistically significantly lower in the smokers' group ( 0.05). The FAZ area was 0.409 0.048 mm in the smokers' group and 0.327 0.055 mm in the control group ( 0.001). The superficial foveal VD was 31.35 5.79% in the smokers' group and 33.63 4.78% in the control group ( 0.06). The deep foveal VD was 39.38 4.56% in the smokers' group and 34.15 6.57% in the control group ( 0.001). The superficial and deep parafoveal VD was 52.09 4.56% and 59.99 2.25% respectively in the smokers' group, and 54.75 2.30% and 55.58 4.69% respectively in the control group ( 0.05). The macular outer retina flow area was 1.29 0.12 mm in the smokers' group and 1.16 0.11 mm in the control group ( 0.001).
Chronic smoking affected the integrity of the macula and optic nerve. It decreased the macular VD, enlarged the FAZ, and increased outer retinal flow area.
利用光相干断层扫描血管造影术（OCTA）研究慢性吸烟对黄斑和视神经完整性的影响。
这是一项前瞻性、对照研究，纳入了 160 名健康受试者的右眼（80 名吸烟者组和 80 名对照组）。对所有受试者进行 OCTA 扫描。测量并分析所有黄斑区各层厚度、视盘周围视网膜神经纤维层（RNFL）厚度、黄斑神经节细胞复合体（GCC）厚度、浅层和深层黄斑血管密度、中心凹无血管区（FAZ）面积以及黄斑外视网膜血流面积。
吸烟者组的一些黄斑区各层、下方 GCC 和 RNFL 厚度明显较薄（ 0.05）。吸烟者组 FAZ 面积为 0.409 0.048 mm，对照组为 0.327 0.055 mm（ 0.001）。吸烟者组浅层黄斑中心凹血管密度为 31.35 5.79%，对照组为 33.63 4.78%（ 0.06）。吸烟者组深层黄斑中心凹血管密度为 39.38 4.56%，对照组为 34.15 6.57%（ 0.001）。吸烟者组浅层和深层黄斑旁血管密度分别为 52.09 4.56%和 59.99 2.25%，对照组分别为 54.75 2.30%和 55.58 4.69%（ 0.05）。吸烟者组黄斑外视网膜血流面积为 1.29 0.12 mm，对照组为 1.16 0.11 mm（ 0.001）。
慢性吸烟影响黄斑和视神经的完整性。它降低了黄斑血管密度，扩大了 FAZ，并增加了外视网膜血流面积。
