针对心肌梗死的细胞类型特异性 microRNA 疗法。
Cell type-specific microRNA therapies for myocardial infarction.
机构信息
Department of Medicine, Columbia University, New York, NY 10032, USA.
Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
出版信息
Sci Transl Med. 2021 Feb 10;13(580). doi: 10.1126/scitranslmed.abd0914.
Abstract
Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.
摘要
目前的干预措施未能在梗塞后恢复受损的心肌，因此迫切需要开发心脏保护策略。越来越受到关注的是利用 microRNAs 通过特异性靶向 mRNAs 来控制基因表达的治疗用途。在这篇综述中，我们讨论了当前基于 microRNA 的治疗策略，描述了关键 microRNAs 的结果和局限性，重点关注靶细胞类型和分子途径。最后，我们对 microRNA 治疗心肌梗塞的前景提出了看法，强调了突出的挑战和新兴策略。
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