对非洲的三百万个基因组进行测序。
Sequence three million genomes across Africa.
出版信息
Nature. 2021 Feb;590(7845):209-211. doi: 10.1038/d41586-021-00313-7.
Abstract
Capture the full scope of variation to improve health care, equity and medical research globally.
摘要
捕捉全貌的变异，以改善全球的医疗保健、公平和医学研究。
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2
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Nature. 2020 Oct;586(7831):683-692. doi: 10.1038/s41586-020-2817-4. Epub 2020 Oct 28.
3
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