Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Psychopharmacology (Berl). 2021 Jun;238(6):1531-1539. doi: 10.1007/s00213-021-05783-1. Epub 2021 Feb 11.
To investigate the protective effect of phosphatidylserine liposomes (PSL) on post-stroke (ST) injuries such as neuroinflammation and depression in mice.
Brain ischemia was induced via the right unilateral common carotid artery occlusion model. Then, behavioral assessments including the forced swimming test (FST) and tail suspension test (TST) were used to evaluate the antidepressant-like effect of PSL. Moreover, inflammatory cytokines changes in the hippocampus including TNF-α and IL-10 levels as well as the number of survived neurons were evaluated in ST mice using immunohistochemistry (IHC).
A significant reduction of the immobility time in both behavioral tests indicated the antidepressant activity of PSL. Moreover, the number of viable neurons increased significantly with PSL treatment, which was similar to control group, compared to the untreated ST group. IHC analysis of ST mice receiving PSL showed a significant reduction in TNF-α and IL-10 levels in the inflamed hippocampus of mice.
Oral PSL may improve post-stroke depression (PSD) through its anti-inflammatory properties.
研究磷脂酰丝氨酸脂质体（PSL）对脑缺血后损伤（如神经炎症和抑郁）的保护作用。
通过右侧颈总动脉闭塞模型诱导脑缺血。然后，采用强迫游泳试验（FST）和悬尾试验（TST）评估 PSL 的抗抑郁样作用。此外，通过免疫组织化学（IHC）评估海马体中 TNF-α 和 IL-10 水平等炎症细胞因子的变化以及存活神经元的数量。
两种行为测试中，不动时间明显减少，表明 PSL 具有抗抑郁活性。此外，与未治疗的 ST 组相比，PSL 治疗后存活神经元的数量显著增加，与对照组相似。接受 PSL 治疗的 ST 小鼠的 IHC 分析显示，炎症海马体中的 TNF-α 和 IL-10 水平显著降低。
口服 PSL 可能通过其抗炎特性改善脑卒中后抑郁（PSD）。
