Department of Cell Biology and Cancer Science, Rappaport Technion Integrated Cancer Center (TICC), Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Department of Immunology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
FEBS Lett. 2021 May;595(9):1322-1327. doi: 10.1002/1873-3468.14057. Epub 2021 Mar 11.
The gut microbiota and the immune system have co-evolved to interact and cooperate in many ways. A recent study characterizing the immunomodulatory effects of over 60 different human-derived gut microbes across phyla showed that bacteria-induced immunomodulations are not dictated by the bacterial phylogeny. Yet, it remains unclear whether strains from the same species induce the same immunomodulatory effects on the host. We analyzed the strain-level data from this recent study and found that strains from the same species can induce distinct and sometimes even opposing immunophenotypes. Hence, we suggest that the immunomodulatory capabilities of gut bacteria can be strain-specific.
肠道微生物群和免疫系统共同进化，以多种方式相互作用和合作。最近的一项研究描述了 60 多种不同的人类肠道微生物在门水平上的免疫调节作用，表明细菌诱导的免疫调节不受细菌系统发育的支配。然而，目前尚不清楚同一种的菌株是否会对宿主产生相同的免疫调节作用。我们分析了最近这项研究的菌株水平数据，发现同一种的菌株可以诱导不同的甚至相反的免疫表型。因此，我们认为肠道细菌的免疫调节能力可能具有菌株特异性。
