短链脂肪酸对人类健康中代谢和炎症过程的影响。

Effects of short chain fatty acids on metabolic and inflammatory processes in human health.

机构信息

Instituto de Nutrigenética y Nutrigenómica Traslacional, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, Mexico.

出版信息

Biochim Biophys Acta Mol Cell Biol Lipids. 2021 May;1866(5):158900. doi: 10.1016/j.bbalip.2021.158900. Epub 2021 Feb 9.

DOI:10.1016/j.bbalip.2021.158900

PMID:33571672

Abstract

Butyrate, propionate, and acetate are short-chain fatty acids (SCFAs) mainly produced by bacterial metabolism in the human gut after dietary fiber intake. SCFAs are considered important for health maintenance by promoting lipid, glucose, and immune homeostasis with an adequate composition of intestinal microbiota, including other beneficial effects like providing protection against colorectal cancer. Therapies with exogenous SCFAs have been proposed to reduce inflammation in intestinal diseases that result from SCFA dysbiosis and cause mucosal inflammation. The aim of this mini-review was to provide an overview of the importance of SCFAs on metabolic and inflammatory processes as well as their role in treating chronic inflammatory disorders.

摘要

丁酸、丙酸和乙酸是短链脂肪酸（SCFAs），主要在膳食纤维摄入后由人体肠道内的细菌代谢产生。SCFAs 被认为对健康维持很重要，通过促进脂类、葡萄糖和免疫的动态平衡以及肠道微生物菌群的适当组成，发挥着重要作用，包括预防结直肠癌等其他有益作用。用外源性 SCFAs 进行治疗，被提议用来减少因 SCFA 失调引起的肠道疾病的炎症，这种疾病会导致黏膜炎症。本综述的目的是概述 SCFAs 在代谢和炎症过程中的重要性，以及它们在治疗慢性炎症性疾病中的作用。