原卟啉IX、焦脱镁叶绿酸-a及光卟啉在不同条件下的光物理性质
Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin in Different Conditions.
作者信息
Myrzakhmetov Bauyrzhan, Arnoux Philippe, Mordon Serge, Acherar Samir, Tsoy Irina, Frochot Céline
机构信息
LRGP UMR 7274, CNRS, University of Lorraine, 54000 Nancy, France.
Department of Chemistry and Chemical Technology, M.Kh. Dulaty Taraz Regional University, Taraz 080012, Kazakhstan.
出版信息
Pharmaceuticals (Basel). 2021 Feb 9;14(2):138. doi: 10.3390/ph14020138.
Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of reactive oxygen species (ROS) especially singlet oxygen (O). In this study, the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of protoporphyrin IX, pyropheophorbide-a, and Photofrin were investigated by UV-visible absorption, fluorescence emission, singlet oxygen emission, and time-resolved fluorescence spectroscopies.
光动力疗法（PDT）是一种针对恶性或病变组织的创新治疗方法。PDT的有效性取决于光剂量测定、氧气供应以及光敏剂（PS）的特性。根据介质的不同，PS的光物理性质会发生变化，导致荧光发射增加或减少，以及活性氧（ROS）尤其是单线态氧（O）的形成。在本研究中，通过紫外可见吸收光谱、荧光发射光谱、单线态氧发射光谱和时间分辨荧光光谱，研究了溶剂极性、粘度、浓度、温度和pH介质对原卟啉IX、焦脱镁叶绿酸-a和血卟啉衍生物光物理性质的影响。
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