Dhaini Batoul, Arnoux Philippe, Daouk Joël, Lux François, Tillement Olivier, Hagège Agnès, Hamieh Tayssir, Shafirstein Gal, Frochot Céline
Université de Lorraine, CNRS, LRGP, 54600 Nancy, France.
Laboratory of Materials, Catalysis, Environment and Analytical Methods (MCEMA), Faculty of Sciences I, Lebanese University, Beirut 1102, Lebanon.
Pharmaceuticals (Basel). 2024 Aug 5;17(8):1033. doi: 10.3390/ph17081033.
Photodynamic therapy is an accepted therapy cancer treatment. Its advantages encourage researchers to delve deeper. The use of nanoparticles in PDT has several advantages including the passive targeting of cancer cells. The aim of this article is to evaluate the effectiveness of AGuIX nanoparticles (activation and guiding of irradiation by X-ray) in the presence or absence of a photosensitizer, Photofrin, under illumination of 630 nm or under X-ray irradiation. The goal is to improve local tumor control by combining PDT with low-dose-X-ray-activated NPs in the treatment of locally advanced metastatic lung cancer. The study of the energy transfer, which occurs after excitation of Gd/Tb chelated in AGuIX in the presence of Photofrin, was carried out. We could observe the formation of singlet oxygen after the light or X-ray excitation of Gd and Tb that was not observed for AGuIX or Photofrin alone, proving that it is possible to realize energy transfer between both compounds.
光动力疗法是一种被认可的癌症治疗方法。其优势促使研究人员深入探究。在光动力疗法中使用纳米颗粒有诸多优点，包括对癌细胞的被动靶向作用。本文的目的是评估在存在或不存在光敏剂卟吩姆钠的情况下，在630纳米光照或X射线照射下，AGuIX纳米颗粒（通过X射线激活和引导辐射）的有效性。目标是通过在局部晚期转移性肺癌治疗中将光动力疗法与低剂量X射线激活的纳米颗粒相结合来改善局部肿瘤控制。对在卟吩姆钠存在的情况下AGuIX中螯合的钆/铽激发后发生的能量转移进行了研究。我们可以观察到钆和铽在光或X射线激发后单线态氧的形成，而单独的AGuIX或卟吩姆钠则未观察到这种现象，这证明两种化合物之间能够实现能量转移。
