Weinberger M H, Cohen S J, Miller J Z, Luft F C, Grim C E, Fineberg N S
Department of Medicine, Indiana University School of Medicine, Indianapolis 46223.
JAMA. 1988 May 6;259(17):2561-5.
To examine the effect of modest dietary sodium ion restriction in treated hypertensive individuals, we studied 114 hypertensive patients undergoing individualized dietary counseling with a research dietitian to achieve reduction in dietary sodium ion intake. A significant reduction in mean sodium ion intake was achieved after the first of three lessons and was maintained for 30 weeks with no change in potassium ion intake. Significant falls in blood pressure and body weight were observed with no significant correlations noted between the two variables, implying independence of these effects. Individuals compliant with the dietary sodium ion restriction goal (urinary excretion, less than or equal to 80 mmol/d [less than or equal to 80 mEq/24 h]) were more likely to have a reduction in number of medications than those not reaching that goal. Ninety-eight of the 114 patients completed the entire 30 weeks. Patients who dropped out tended to have lower diastolic blood pressures and required fewer medications for blood pressure control than those who completed the 30 weeks. For these reasons, patients in the former group may have been less highly motivated to complete the study. These observations suggest that modest dietary sodium ion restriction is feasible in treated hypertensive patients and that adherence to such a regimen may permit blood pressure control with fewer medications.
为了研究适度限制饮食中钠离子对接受治疗的高血压患者的影响,我们对114名高血压患者进行了研究,这些患者在一位研究营养师的指导下接受个性化饮食咨询,以减少饮食中钠离子的摄入量。在三节课中的第一节课后,平均钠离子摄入量显著降低,并在30周内保持稳定,而钾离子摄入量没有变化。观察到血压和体重显著下降,且这两个变量之间没有显著相关性,这意味着这些影响是独立的。与未达到饮食中钠离子限制目标(尿排泄量小于或等于80 mmol/d [小于或等于80 mEq/24 h])的患者相比,符合该目标的患者更有可能减少用药数量。114名患者中有98名完成了整个30周的研究。退出研究的患者舒张压往往较低,且与完成30周研究的患者相比,控制血压所需的药物较少。由于这些原因,前一组患者完成研究的积极性可能较低。这些观察结果表明,适度限制饮食中钠离子在接受治疗的高血压患者中是可行的,坚持这样的方案可能允许用更少的药物控制血压。