Mahmoud Abdallah G, Sousa Sílvia A, Guedes da Silva M Fátima C, Martins Luísa M D R S, Leitão Jorge H
Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11795, Egypt.
Antibiotics (Basel). 2024 Jul 13;13(7):647. doi: 10.3390/antibiotics13070647.
The novel hydrosoluble silver coordination polymer [Ag(NO)(μ-1κ;2',″-TPM)] () (TPM = tris(1-pyrazol-1-yl)ethanol) was obtained and characterized. While single crystal X-ray diffraction analysis of compound disclosed an infinite 1D helical chain structure in the solid state, NMR analysis in polar solvents confirmed the mononuclear nature of compound in solution. Compound and the analogue [Ag(μ-1κ;2',″-TPMS)] () (TPMS = tris(1-pyrazol-1-yl)methane sulfonate) were evaluated with regard to their antimicrobial activities towards the Gram-negative , , and , the Gram-positive , and the fungal species and . Compound exhibited minimal inhibitory concentration (MIC) values ranging from 2 to 7.7 µg/mL towards the tested Gram-negative bacteria, 18 µg/mL towards the Gram-positive , and 15 and 31 µg/mL towards and , respectively. Compound was less effective towards the tested bacteria, with MIC values ranging from 15 to 19.6 µg/mL towards the Gram-negative bacteria and 51 µg/mL towards ; however, it was more effective against and , with MIC values of about 6 µg/mL towards these fungal species. The toxicity of compounds and was assessed by evaluating the survival of the model organism to concentrations of up to 100 µg/mL. The value of 50% lethality (LD) could only be estimated as 73.2 µg/mL for compound at 72 h, otherwise LD was >100 µg/mL for both compounds and . These results indicate compounds and as novel silver complexes with interesting antimicrobial properties towards bacterial and fungal pathogens.
新型水溶性银配位聚合物Ag(NO)(μ-1κ;2',″-TPM)(TPM = 三(1-吡唑-1-基)乙醇)已被制备并表征。虽然化合物的单晶X射线衍射分析揭示了其固态下的无限一维螺旋链结构，但在极性溶剂中的核磁共振分析证实了化合物在溶液中的单核性质。对化合物和类似物Ag(μ-1κ;2',″-TPMS)(TPMS = 三(1-吡唑-1-基)甲磺酸盐)针对革兰氏阴性菌、、和、革兰氏阳性菌以及真菌物种和的抗菌活性进行了评估。化合物对测试的革兰氏阴性菌的最低抑菌浓度(MIC)值范围为2至7.7μg/mL，对革兰氏阳性菌为18μg/mL，对和分别为15和31μg/mL。化合物对测试细菌的效果较差，对革兰氏阴性菌的MIC值范围为15至19.6μg/mL，对为51μg/mL；然而，它对和更有效，对这些真菌物种的MIC值约为6μg/mL。通过评估模式生物在高达100μg/mL浓度下的存活率来评估化合物和的毒性。化合物在72小时时的50%致死浓度(LD)只能估计为73.2μg/mL，否则化合物和的LD均>100μg/mL。这些结果表明化合物和是对细菌和真菌病原体具有有趣抗菌特性的新型银配合物。
