Heij Lara R, Tan Xiuxiang, Kather Jakob N, Niehues Jan M, Sivakumar Shivan, Heussen Nicole, van der Kroft Gregory, Damink Steven W M Olde, Lang Sven, Aberle Merel R, Luedde Tom, Gaisa Nadine T, Bednarsch Jan, Liu Drolaiz H W, Cleutjens Jack P M, Modest Dominik P, Neumann Ulf P, Wiltberger Georg J
Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.
J Clin Med. 2021 Jan 30;10(3):490. doi: 10.3390/jcm10030490.
B cells and tertiary lymphoid structures (TLS) are reported to be important in survival in cancer. Pancreatic Cancer (PDAC) is one of the most lethal cancer types, and currently, it is the seventh leading cause of cancer-related death worldwide. A better understanding of tumor biology is pivotal to improve clinical outcome. The desmoplastic stroma is a complex system in which crosstalk takes place between cancer-associated fibroblasts, immune cells and cancer cells. Indirect and direct cellular interactions within the tumor microenvironment (TME) drive key processes such as tumor progression, metastasis formation and treatment resistance. In order to understand the aggressiveness of PDAC and its resistance to therapeutics, the TME needs to be further unraveled. There are some limited data about the influence of nerve fibers on cancer progression. Here we show that small nerve fibers are located at lymphoid aggregates in PDAC. This unravels future pathways and has potential to improve clinical outcome by a rational development of new therapeutic strategies.
据报道，B细胞和三级淋巴结构（TLS）在癌症生存中很重要。胰腺癌（PDAC）是最致命的癌症类型之一，目前是全球癌症相关死亡的第七大主要原因。更好地了解肿瘤生物学对于改善临床结果至关重要。促纤维增生性基质是一个复杂的系统，其中癌症相关成纤维细胞、免疫细胞和癌细胞之间会发生相互作用。肿瘤微环境（TME）内的间接和直接细胞相互作用驱动着肿瘤进展、转移形成和治疗抗性等关键过程。为了了解PDAC的侵袭性及其对治疗的抗性，需要进一步阐明TME。关于神经纤维对癌症进展影响的数据有限。在这里，我们表明小神经纤维位于PDAC的淋巴聚集处。这揭示了未来的研究方向，并有可能通过合理开发新的治疗策略来改善临床结果。
