Kamal Ritul, Srivastava Anup Kumar, Kesavachandran Chandrasekharan Nair, Bihari Vipin, Singh Amarnath
Epidemiology Lab, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
Department of Statistics, University of Lucknow, Lucknow, India.
Int J Environ Health Res. 2022 Jun;32(6):1403-1417. doi: 10.1080/09603123.2021.1887460. Epub 2021 Feb 12.
Chronic Obstructive Pulmonary Disease (COPD) is attributable to household air pollution and is known to increase the Disability Adjusted Life Years (DALYs), morbidity and mortality and women are most susceptible groups for the exposure. In order to understand the global risk among women with COPD due to exposure of household air pollutants, an evidence-based systematic review and meta-analysis was conducted. Meta regression analysis was carried out to identify potential sources of heterogeneity. The summary estimates of the included studies showed higher prevalence of COPD due to biomass fuel exposure in women. Clinical diagnosis has shown more risk of COPD prevalence compared to diagnosis based on spirometer test alone. However, the data between included studies for both clinical and spirometry-based studies showed higher heterogeneity. The present meta-data analysis has shown that household air pollutants may be a factor associated with increased risk of COPD in women.
慢性阻塞性肺疾病(COPD)可归因于家庭空气污染,已知会增加伤残调整生命年(DALYs)、发病率和死亡率,而女性是最易受暴露影响的群体。为了解家庭空气污染物暴露导致的全球女性慢性阻塞性肺疾病风险,开展了一项基于证据的系统评价和荟萃分析。进行了Meta回归分析以确定潜在的异质性来源。纳入研究的汇总估计显示,女性因生物质燃料暴露导致的慢性阻塞性肺疾病患病率更高。与仅基于肺活量计测试的诊断相比,临床诊断显示慢性阻塞性肺疾病患病率的风险更高。然而,纳入研究中临床研究和基于肺活量测定法的研究数据均显示出较高的异质性。目前的荟萃数据分析表明,家庭空气污染物可能是女性慢性阻塞性肺疾病风险增加的一个相关因素。