Zhang Xiaofan, Wang Huiyun, Xu Yangrong, Luan Mingzhu, Zhao Fenglan, Meng Qingguo
School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
College of Pharmacy, Jining Medical University, Shandong Province, Rizhao, 27682, China.
Mini Rev Med Chem. 2021;21(15):2020-2038. doi: 10.2174/1389557521666210126142051.
Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF- κB/ICAM-1/JAK/STAT signaling pathways, etc. In recent years, an increased number of interesting research work has been carried out on the anti-inflammatory activity and mechanisms of OA derivatives, such as acyloxyimino derivative, 3-acetylated derivatives, novel 3,5-disubstituted isoxazoles derivatives, acetate, ester derivatives and oximes derivatives. The review summaries and highlights the updated advances on the anti-inflammatory activity and mechanism of OA and its derivatives.
齐墩果酸可通过激活垂体-肾上腺皮质系统、抑制前列腺素的合成或释放、抑制内皮细胞内毒素介导的高迁移率族蛋白B1释放或调节丝裂原活化蛋白激酶、磷脂酰肌醇-3激酶/蛋白激酶B/核因子κB/细胞间黏附分子-1/ Janus激酶/信号转导和转录激活因子信号通路等抑制水肿并对炎症表现出明显的抑制活性。近年来，针对齐墩果酸衍生物如酰氧基肟衍生物、3-乙酰化衍生物、新型3,5-二取代异恶唑衍生物、乙酸酯、酯衍生物和肟衍生物的抗炎活性及作用机制开展了越来越多有趣的研究工作。本文综述并重点介绍了齐墩果酸及其衍生物抗炎活性和作用机制的最新进展。
