Department of Biotechnology, Delhi Technological University, Delhi,India.
Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida,India.
Curr Pharm Biotechnol. 2022;23(1):123-139. doi: 10.2174/1389201022666210211123539.
Diseases with a significant loss of neurons, structurally and functionally are termed as neurodegenerative diseases. Due to the present therapeutic interventions and progressive nature of diseases, a variety of side effects have risen up, thus leading the patients to go for an alternative medication. The role of medicinal plants in such cases has been beneficial because of their exhibition via different cellular and molecular mechanisms. Alleviation in inflammatory responses, suppression of the functionary aspect of pro-inflammatory cytokines like a tumor, improvement in antioxidative properties is among few neuroprotective mechanisms of traditional plants. Variation in transcription and transduction pathways plays a vital role in the preventive measures of plants in such diseases. Neurodegenerative diseases are generally caused by the depletion of proteins, oxidative and inflammatory stress, environmental changes and so on, with aging being the most important cause. Natural compounds can be used in order to treat neurodegenerative diseases Medicinal plants such as Ginseng, Withania somnifera, Bacopa monnieri, Ginkgo biloba, etc. are some of the medicinal plants for the prevention of neurological symptoms. This review deals with the use of different medicinal plants for the prevention of neurodegenerative diseases.
具有大量神经元结构和功能丧失的疾病被称为神经退行性疾病。由于目前的治疗干预措施和疾病的进展性质，出现了各种副作用，因此导致患者寻求替代药物。药用植物在这种情况下发挥了有益的作用，因为它们通过不同的细胞和分子机制发挥作用。减轻炎症反应、抑制肿瘤等促炎细胞因子的功能、改善抗氧化特性是传统植物的几种神经保护机制之一。转录和转导途径的变化在植物预防此类疾病中起着至关重要的作用。神经退行性疾病通常是由蛋白质耗竭、氧化和炎症应激、环境变化等引起的，衰老是最重要的原因。可以使用天然化合物来治疗神经退行性疾病，如人参、南非醉茄、假马齿苋、银杏等药用植物是预防神经症状的一些药用植物。本综述讨论了使用不同药用植物预防神经退行性疾病。
