Neuropharmacology Laboratory, Indian Institute of Integrative Medicine-CSIR, Sanat Nagar, Srinagar, 190005, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Neuropharmacology Laboratory, Indian Institute of Integrative Medicine-CSIR, Sanat Nagar, Srinagar, 190005, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
J Ethnopharmacol. 2020 Jun 28;256:112769. doi: 10.1016/j.jep.2020.112769. Epub 2020 Mar 30.
Withania somnifera (L.) Dunal also known as 'Ashwaghanda' in Sanskrit and as 'Indian Winter Cherry' in english. is an important medicinal herb in India. It is widely used in Indian systems of medicine as an adaptogen, nerve tonic, anti-stress, memory enhancer and against cognitive deficits, insomnia, anxiety, infectious diseases, infertility, rheumatoid arthritis and gout over thousands of years. Its formulations are mainly used in Unani and Ayurvedic system of medicine. It is a remarkable centuries old herbal Rasayana used to treat neuronal ailments and is known as ''Sattvic Kapha Rasayana.
To review neuroprotective properties of Withania somnifera (L.)extract as well as its active constituents in neurodegenerative diseases and other neurological ailments.
The sources of information used in present article include Indian system of Medicine reports on the use of natural products, Medicinal books, research articles and scientific databases like PubMed, Google Scholar, Web of Science, Science-Direct, SciFinder, ACS Publications and Wiley Online Library.
Research reports based largely on preclinical studies as well as few clinical trials have highlighted the neuroprotective role of Ashwagandha against many neurodegenerative diseases including Alzheimer's, Huntington's and Parkinson's disease. The protective effects of Ashwagandha were accomplished by restoring mitochondrial and endothelial function, mitigation of apoptosis, inflammation and oxidative stress mechanisms.
In this review, we recapitulated neuroprotective properties of Ashwagandha extracts and/or its major constituents and discussed their mechanisms of action and potential therapeutic applications. The pre-clinical as well as clinical studies suggest the use of Withania somnifera (L.) against neurodegenerative disease. However, extensive studies are warranted to validate the use of extract or its single constituents for its clinical use.
南非醉茄（L.）邓纳尔，在梵文中也被称为“阿什瓦甘达”，在英文中被称为“印度冬樱桃”。是印度的一种重要药用植物。几千年来，它在印度医学系统中被广泛用作适应原、神经滋补剂、抗应激、增强记忆力、治疗认知障碍、失眠、焦虑、传染病、不孕、类风湿性关节炎和痛风。它的配方主要用于顺势疗法和阿育吠陀医学体系。这是一种具有数百年历史的草药 Rasayana，用于治疗神经元疾病，被称为“纯净的 Kapha Rasayana”。
综述南非醉茄（L.）提取物及其在神经退行性疾病和其他神经疾病中的活性成分的神经保护特性。
本文使用的信息来源包括印度医学系统关于天然产物使用的报告、药用书籍、研究文章以及 PubMed、Google Scholar、Web of Science、Science-Direct、SciFinder、ACS 出版物和 Wiley Online Library 等科学数据库。
基于大量临床前研究以及少数临床试验的研究报告强调了 Ashwagandha 对许多神经退行性疾病（包括阿尔茨海默病、亨廷顿病和帕金森病）的神经保护作用。 Ashwagandha 的保护作用是通过恢复线粒体和内皮功能、减轻细胞凋亡、炎症和氧化应激机制来实现的。
在本综述中，我们总结了 Ashwagandha 提取物及其主要成分的神经保护特性，并讨论了它们的作用机制和潜在的治疗应用。临床前和临床研究表明南非醉茄（L.）可用于治疗神经退行性疾病。然而，需要进行广泛的研究来验证提取物或其单一成分的临床用途。
