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硫酸铵和氯化钠对甲磺酸乙酯诱导的V79仓鼠细胞染色体畸变和次黄嘌呤-鸟嘌呤磷酸核糖转移酶基因突变的影响。

Influence of ammonium sulfate and sodium chloride on ethyl methanesulfonate-induced chromosomal aberrations and HPRT mutations in V79 hamster cells.

作者信息

Nowak C

机构信息

Institut für Genetik, Freie Universität Berlin, F.R.G.

出版信息

Mutat Res. 1988 Mar-Apr;207(3-4):147-52. doi: 10.1016/0165-7992(88)90079-6.

DOI:10.1016/0165-7992(88)90079-6
PMID:3357491
Abstract

V79 hamster cells were mutagenized with ethyl methanesulfonate (EMS) and immediately afterwards posttreated with hypertonic solutions of sodium chloride or ammonium sulfate. The posttreatment had a clear effect on chromosomal aberrations, but TGr mutations were only enhanced by ammonium sulfate, but not by sodium chloride posttreatment. It is suggested that hypertonic salt posttreatment leads to conformational changes in the DNA, resulting in an increase in TGr mutations and chromosomal aberrations.

摘要

用甲磺酸乙酯（EMS）诱变V79仓鼠细胞，随后立即用氯化钠或硫酸铵的高渗溶液进行后处理。后处理对染色体畸变有明显影响，但TGr突变仅在经硫酸铵后处理时增加，经氯化钠后处理则未增加。有人提出，高渗盐后处理会导致DNA构象改变，从而导致TGr突变和染色体畸变增加。

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