Khudyakov Aleksandr, Ahmed Rafsan, Huynh Chi Doan, Dehghani Amir, Li Zhonghua, Rose Michael
SUNY Downstate Internal Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.
Kings County Department of Pathology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.
Case Rep Infect Dis. 2021 Jan 27;2021:4381254. doi: 10.1155/2021/4381254. eCollection 2021.
Mucormycosis is a highly invasive and rapidly progressing form of fungal infection that can be fatal. The infection usually begins after oral or nasal inhalation of fungal spores and can enter the host through a disrupted mucosa or an extraction wound. The organism becomes pathogenic when the host is in an immunocompromised state. There are several clinical presentations of mucormycosis including rhinocerebral, pulmonary, cutaneous, gastrointestinal, disseminated, and miscellaneous forms. The most common clinical presentation of mucormycosis is the rhinocerebral form which has a high predilection for patients with diabetes and metabolic acidosis. An indolent disease course taking weeks to months of this infection is rare making it difficult to diagnose. Therefore, early detection and prompt treatment with surgical and antifungal therapy are very important in achieving good treatment outcomes.
毛霉病是一种具有高度侵袭性且进展迅速的真菌感染形式，可能会致命。感染通常在经口或经鼻吸入真菌孢子后开始，可通过破损的黏膜或拔牙创口进入宿主。当宿主处于免疫功能低下状态时，该病原体就会致病。毛霉病有多种临床表现，包括鼻脑型、肺型、皮肤型、胃肠型、播散型和其他类型。毛霉病最常见的临床表现是鼻脑型，糖尿病和代谢性酸中毒患者对此型有高度易感性。这种感染病程缓慢，持续数周甚至数月，较为罕见，因此难以诊断。所以，早期发现并及时采用手术和抗真菌治疗对于取得良好的治疗效果非常重要。
