• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长链非编码RNA GCC2-AS1的上调促进肺腺癌的恶性表型并与不良预后相关。

Upregulation of Long Non-Coding RNA GCC2-AS1 Facilitates Malignant Phenotypes and Correlated With Unfavorable Prognosis for Lung Adenocarcinoma.

作者信息

Yu Fengqiang, Liang Mingqiang, Wu Weidong, Huang Yu, Zheng Jiantao, Zheng Bin, Chen Chun

机构信息

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Fujian Provincial Key Laboratory of Cardiothoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

出版信息

Front Oncol. 2021 Jan 26;10:628608. doi: 10.3389/fonc.2020.628608. eCollection 2020.

DOI:10.3389/fonc.2020.628608
PMID:33575222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7870869/
Abstract

BACKGROUND

The role played by long noncoding RNA GCC2-AS1 in primary malignant tumors remains poorly understood. This study aimed to determine the expression levels and evaluate the clinical significance and biological effects of GCC2-AS1 in lung adenocarcinoma (LUAD).

METHODS

We used data obtained from tissue samples and the TCGA database to determine the levels of GCC2-AS1 expression LUAD patients, and the prognostic value of those levels. Functional experiments were performed to investigate the effect of GCC2-AS1 on LUAD cells. Genes that were differentially expressed in GCC2-AS1-low and -high groups were analyzed by an enrichment analysis. Additionally, a nomogram model was created and subgroup analyses were performed to further determine the prognostic value of GCC2-AS1 in LUAD.

RESULTS

GCC2-AS1 expression was significantly upregulated in lung adenocarcinoma tissues as compared with normal tissues. Depletion of GCC2-AS1 inhibited the proliferation and invasion of LUAD cells . An elevated level of GCC2-AS1 was strongly correlated with shorter overall survival time and was identified as an independent prognostic marker for LUAD patients. Enrichment analyses conducted using GO, KEGG, and GSEA databases were performed to identify biological pathways that might involve GCC2-AS1. Several subgroups were found to have a significant prognostic value for patients in the GCC2-AS1-low and -high groups.

CONCLUSIONS

Our findings suggest that GCC2-AS1 can serve as a diagnostic and prognostic biomarker for LUAD patients.

摘要

背景

长链非编码RNA GCC2-AS1在原发性恶性肿瘤中所起的作用仍知之甚少。本研究旨在确定GCC2-AS1在肺腺癌（LUAD）中的表达水平，并评估其临床意义和生物学效应。

方法

我们使用从组织样本和TCGA数据库获得的数据来确定LUAD患者中GCC2-AS1的表达水平及其预后价值。进行功能实验以研究GCC2-AS1对LUAD细胞的影响。通过富集分析对在GCC2-AS1低表达和高表达组中差异表达的基因进行分析。此外，创建了列线图模型并进行亚组分析，以进一步确定GCC2-AS1在LUAD中的预后价值。

结果

与正常组织相比，肺腺癌组织中GCC2-AS1表达显著上调。GCC2-AS1的缺失抑制了LUAD细胞的增殖和侵袭。GCC2-AS1水平升高与总生存时间缩短密切相关，并被确定为LUAD患者的独立预后标志物。使用GO、KEGG和GSEA数据库进行富集分析，以确定可能涉及GCC2-AS1的生物学途径。发现几个亚组对GCC2-AS1低表达和高表达组的患者具有显著的预后价值。

结论

我们的研究结果表明，GCC2-AS1可作为LUAD患者的诊断和预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f843a532b7c6/fonc-10-628608-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/1e385cb8d198/fonc-10-628608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f3b4659ed6a8/fonc-10-628608-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/87c9a7314607/fonc-10-628608-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/955ecd6dc06c/fonc-10-628608-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f24094f7bf15/fonc-10-628608-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f843a532b7c6/fonc-10-628608-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/1e385cb8d198/fonc-10-628608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f3b4659ed6a8/fonc-10-628608-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/87c9a7314607/fonc-10-628608-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/955ecd6dc06c/fonc-10-628608-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f24094f7bf15/fonc-10-628608-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3796/7870869/f843a532b7c6/fonc-10-628608-g006.jpg

相似文献

1
Upregulation of Long Non-Coding RNA GCC2-AS1 Facilitates Malignant Phenotypes and Correlated With Unfavorable Prognosis for Lung Adenocarcinoma.长链非编码RNA GCC2-AS1的上调促进肺腺癌的恶性表型并与不良预后相关。
Front Oncol. 2021 Jan 26;10:628608. doi: 10.3389/fonc.2020.628608. eCollection 2020.
2
Identification and validation of an autophagy-related long non-coding RNA signature as a prognostic biomarker for patients with lung adenocarcinoma.一种自噬相关长链非编码RNA特征作为肺腺癌患者预后生物标志物的鉴定与验证
J Thorac Dis. 2021 Feb;13(2):720-734. doi: 10.21037/jtd-20-2803.
3
LncRNA-AC068228.1 Is a Novel Prognostic Biomarker That Promotes Malignant Phenotypes in Lung Adenocarcinoma.长链非编码RNA-AC068228.1是一种新型的预后生物标志物，可促进肺腺癌的恶性表型。
Front Oncol. 2022 Feb 23;12:856655. doi: 10.3389/fonc.2022.856655. eCollection 2022.
4
LncRNA PCBP1-AS1 correlated with the functional states of cancer cells and inhibited lung adenocarcinoma metastasis by suppressing the EMT progression.长链非编码 RNA PCBP1-AS1 与癌细胞的功能状态相关，并通过抑制 EMT 进展抑制肺腺癌转移。
Carcinogenesis. 2021 Jul 16;42(7):931-939. doi: 10.1093/carcin/bgab047.
5
lncRNA VIM-AS1 acts as a prognostic biomarker and promotes apoptosis in lung adenocarcinoma.长链非编码RNA VIM-AS1作为一种预后生物标志物，促进肺腺癌细胞凋亡。
J Cancer. 2023 May 15;14(8):1417-1426. doi: 10.7150/jca.83639. eCollection 2023.
6
Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.SEC61G 在肺腺癌中的预后价值：基于生物信息学和体外验证的综合研究。
BMC Cancer. 2021 Nov 13;21(1):1216. doi: 10.1186/s12885-021-08957-4.
7
Metastasis-related long non-coding RNAs AL359220.1, SH3BP5-AS1 and ZF-AS1 are significant for prognostic assessment of lung adenocarcinoma.转移相关长链非编码 RNA AL359220.1、SH3BP5-AS1 和 ZF-AS1 对肺腺癌的预后评估具有重要意义。
Aging (Albany NY). 2023 Aug 10;15(15):7551-7564. doi: 10.18632/aging.204923.
8
A Novel Long Non-Coding RNA, SOX21-AS1, Indicates a Poor Prognosis and Promotes Lung Adenocarcinoma Proliferation.一种新型长链非编码RNA，SOX21-AS1，提示预后不良并促进肺腺癌增殖。
Cell Physiol Biochem. 2017;42(5):1857-1869. doi: 10.1159/000479543. Epub 2017 Jul 27.
9
Comprehensive Analysis of NPSR1-AS1 as a Novel Diagnostic and Prognostic Biomarker Involved in Immune Infiltrates in Lung Adenocarcinoma.NPSR1-AS1作为参与肺腺癌免疫浸润的新型诊断和预后生物标志物的综合分析
J Oncol. 2022 Oct 15;2022:2099327. doi: 10.1155/2022/2099327. eCollection 2022.
10
Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma.构建并分析肺腺癌胸腔积液外泌体 lncRNAs 的表达谱。
J Clin Lab Anal. 2022 Dec;36(12):e24777. doi: 10.1002/jcla.24777. Epub 2022 Nov 25.

引用本文的文献

1
KM04416 suppressed lung adenocarcinoma progression by promoting immune infiltration.KM04416 通过促进免疫浸润抑制肺腺癌进展。
J Cardiothorac Surg. 2024 Jul 25;19(1):465. doi: 10.1186/s13019-024-02971-w.
2
Integrated Bioinformatics and Experimental Validation to Identify a Disulfidptosis-Related lncRNA Model for Prognostic Prediction in Papillary Renal Cell Carcinoma.整合生物信息学与实验验证以鉴定用于乳头状肾细胞癌预后预测的二硫化物化相关lncRNA模型
Comb Chem High Throughput Screen. 2025;28(5):883-898. doi: 10.2174/0113862073303084240403051346.
3
Insight into the lncRNA-mRNA Co-Expression Profile and ceRNA Network in Lipopolysaccharide-Induced Acute Lung Injury.

本文引用的文献

1
Microbial Community Analysis of Saliva and Biopsies in Patients With Oral Lichen Planus.口腔扁平苔藓患者唾液和活检组织的微生物群落分析
Front Microbiol. 2020 May 5;11:629. doi: 10.3389/fmicb.2020.00629. eCollection 2020.
2
Downregulation of the circadian rhythm regulator HLF promotes multiple-organ distant metastases in non-small cell lung cancer through PPAR/NF-κb signaling.节律调节因子 HLF 的下调通过 PPAR/NF-κb 信号通路促进非小细胞肺癌的多器官远处转移。
Cancer Lett. 2020 Jul 10;482:56-71. doi: 10.1016/j.canlet.2020.04.007. Epub 2020 Apr 11.
3
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
脂多糖诱导的急性肺损伤中lncRNA-mRNA共表达谱及ceRNA网络的研究
Curr Issues Mol Biol. 2023 Jul 24;45(7):6170-6189. doi: 10.3390/cimb45070389.
4
Identification and validation of a novel cuproptosis-related lncRNA signature for prognosis and immunotherapy of head and neck squamous cell carcinoma.一种用于头颈部鳞状细胞癌预后和免疫治疗的新型铜死亡相关lncRNA特征的鉴定与验证
Front Cell Dev Biol. 2022 Nov 17;10:968590. doi: 10.3389/fcell.2022.968590. eCollection 2022.
5
Identification of a 7-miRNA signature for predicting the prognosis of patients with lung adenocarcinoma.鉴定一个 7 个 miRNA 标志物的签名，用于预测肺腺癌患者的预后。
Exp Biol Med (Maywood). 2022 Apr;247(8):641-657. doi: 10.1177/15353702211067450. Epub 2022 Jan 22.
6
Construction of an immune-related lncRNA signature as a novel prognosis biomarker for LUAD.构建免疫相关 lncRNA 特征作为 LUAD 的新型预后生物标志物。
Aging (Albany NY). 2021 Aug 26;13(16):20684-20697. doi: 10.18632/aging.203455.
7
SMOX expression predicts the prognosis of non-small cell lung cancer.SMOX表达可预测非小细胞肺癌的预后。
Ann Transl Med. 2021 Jul;9(13):1048. doi: 10.21037/atm-21-998.
LINC02273 通过表观遗传增加 AGR2 转录来驱动乳腺癌转移。
Mol Cancer. 2019 Dec 19;18(1):187. doi: 10.1186/s12943-019-1115-y.
4
Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma.预后列线图预测肺大细胞神经内分泌癌的总生存期。
PLoS One. 2019 Sep 27;14(9):e0223275. doi: 10.1371/journal.pone.0223275. eCollection 2019.
5
LINC00957 Acted as Prognostic Marker Was Associated With Fluorouracil Resistance in Human Colorectal Cancer.作为预后标志物的LINC00957与人类结直肠癌中的氟尿嘧啶耐药相关。
Front Oncol. 2019 Aug 21;9:776. doi: 10.3389/fonc.2019.00776. eCollection 2019.
6
Long Non-Coding RNA in the Pathogenesis of Cancers.长链非编码 RNA 在癌症发病机制中的作用。
Cells. 2019 Sep 1;8(9):1015. doi: 10.3390/cells8091015.
7
Emerging roles of lncRNA in cancer and therapeutic opportunities.长链非编码RNA在癌症中的新作用及治疗机会
Am J Cancer Res. 2019 Jul 1;9(7):1354-1366. eCollection 2019.
8
Cancer statistics, 2019.癌症统计数据，2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
9
The Optimal Treatment for Stage IIIA-N2 Non-Small Cell Lung Cancer: A Network Meta-Analysis.IIIaN2 期非小细胞肺癌的最佳治疗方法：网状荟萃分析。
Ann Thorac Surg. 2019 Jun;107(6):1866-1875. doi: 10.1016/j.athoracsur.2018.11.024. Epub 2018 Dec 14.
10
Role of lncRNA and EZH2 Interaction/Regulatory Network in Lung Cancer.长链非编码RNA与EZH2相互作用/调控网络在肺癌中的作用
J Cancer. 2018 Oct 18;9(22):4156-4165. doi: 10.7150/jca.27098. eCollection 2018.